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Preparation method and application of blue-fluorescence carbon quantum dots

A technology of carbon quantum dots and blue fluorescence, applied in the field of carbon quantum dots, can solve the problems of fluorescence quantum yield not reaching the level of semiconductor quantum dots, limitations, immature preparation technology of CQDs, etc., and achieves simple synthesis method and photostability. The effect of good performance and high fluorescence intensity

Active Publication Date: 2019-07-05
YUNNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the preparation technology of CQDs is still immature, and there are some urgent problems to be solved, such as the fluorescence quantum yield has not yet reached the level of semiconductor quantum dots, etc., which are subject to certain restrictions.

Method used

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  • Preparation method and application of blue-fluorescence carbon quantum dots
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  • Preparation method and application of blue-fluorescence carbon quantum dots

Examples

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Embodiment 1

[0028] A preparation method of blue fluorescent carbon quantum dots, the specific steps are as follows:

[0029] (1) dissolving citric acid and hyaluronic acid in water to obtain mixed solution A; wherein the concentration of citric acid in mixed solution A is 12.5mmol / L, and the concentration of hyaluronic acid is 5mmol / L;

[0030] (2) Put the mixed solution A in step (1) under the condition of 180°C for hydrothermal reaction for 6 hours to obtain the HA-CDs solution;

[0031] (3) Dialyze the HA-CDs solution in step (3) through a dialysis membrane for 6 hours, then centrifuge it, then leave it to stand and take the supernatant to obtain blue fluorescent carbon quantum dots; wherein the molecular cut-off of the dialysis membrane is 1000kDa; centrifugation The speed is 6000rpm, and the centrifugation time is 10min;

[0032] In this embodiment, the blue fluorescent carbon quantum dot HA-CDs fluorescence excitation emission spectrum is shown in figure 1 , where the abscissa rep...

Embodiment 2

[0043] A preparation method of blue fluorescent carbon quantum dots, the specific steps are as follows:

[0044] (1) dissolving citric acid and hyaluronic acid in water to obtain mixed solution A; wherein the concentration of citric acid in mixed solution A is 5mmol / L, and the concentration of hyaluronic acid is 8mmol / L;

[0045] (2) Put the mixed solution A in step (1) under the condition of 140° C. for hydrothermal reaction for 12 hours to obtain the HA-CDs solution;

[0046] (3) Dialyze the HA-CDs solution in step (3) through a dialysis membrane for 8 hours, then centrifuge it, then leave it to stand and take the supernatant to obtain blue fluorescent carbon quantum dots; wherein the molecular cut-off of the dialysis membrane is 1100k Da; centrifugation The processing rate is 7000rpm, and the centrifugation time is 15min;

[0047] Selective test of carbon quantum dots for folic acid:

[0048] Take the blue fluorescent carbon quantum dot HA-CDs supernatant of this example,...

Embodiment 3

[0054] A preparation method of blue fluorescent carbon quantum dots, the specific steps are as follows:

[0055] (1) dissolving citric acid and hyaluronic acid in water to obtain mixed solution A; wherein the concentration of citric acid in mixed solution A is 15mmol / L, and the concentration of hyaluronic acid is 7mmol / L;

[0056] (2) Put the mixed solution A in step (1) under the condition of 200°C for hydrothermal reaction for 4 hours to obtain the HA-CDs solution;

[0057] (3) Dialyze the HA-CDs solution in step (3) through a dialysis membrane for 10 hours, then centrifuge it, then leave it to stand and take the supernatant to obtain blue fluorescent carbon quantum dots; wherein the molecular cut-off of the dialysis membrane is 1200k Da; The processing speed is 8000rpm, and the centrifugation processing time is 18min;

[0058] Selective test of carbon quantum dots for folic acid:

[0059] Take the blue fluorescent carbon quantum dot HA-CDs supernatant of this example, dil...

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Abstract

The invention discloses a preparation method and application of blue-fluorescence carbon quantum dots, and belongs to the technical field of carbon quantum dots. Citric acid and hyaluronic acid are dissolved into water to obtain a mixed solution A; the mixed solution A is subjected to a hydrothermal reaction for 4-12 hours to obtain an HA-CDs solution; the HA-CDs solution is dialysed by using a dialysis membrane and then centrifuged, after standing, supernatant liquid is taken to obtain the blue-fluorescence carbon quantum dots. The hyaluronic acid and the citric acid are used as synthesizingraw materials, the novel carbon quantum dots high in fluorescence intensity is synthesized in one step, high-selectivity detection of folic acid can be achieved, and the carbon quantum dots which areeasily synthesized are applied in biological recognition.

Description

technical field [0001] The invention relates to a preparation method and application of blue fluorescent carbon quantum dots, belonging to the technical field of carbon quantum dots. Background technique [0002] Carbon quantum dots (CDs) are a new type of carbon nanomaterials discovered in recent years. They are environmentally friendly fluorescent nanomaterials with similar optical properties to semiconductor quantum dots, but compared with traditional semiconductor quantum dots and organic dyes, luminescent CQDs It has high water solubility, strong chemical stability, easy functionalization, photobleaching resistance, excellent biological properties, good biocompatibility, and has potential applications in biomedicine (bioimaging, biosensing, drug delivery, etc.) prospect. At the same time, CQDs also have excellent photoelectric properties, which can be used as electron donors and electron acceptors, which makes them have a wide range of applications in the fields of opt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B32/15C09K11/65B82Y20/00G01N21/64
CPCC01B32/15C09K11/65B82Y20/00G01N21/6428G01N2021/6432
Inventor 凌剑文秋林杨艳菊王俊刘安勇
Owner YUNNAN UNIV
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