Application of PBK as ovarian cancer cisplatin-resistant target

A technology for ovarian cancer and cisplatin, which is applied in the field of anti-ovarian cancer drugs and can solve problems such as unseen research on the relationship

Active Publication Date: 2019-07-19
SHANDONG UNIV QILU HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the relationship between PBK and ovarian cancer development and cisplatin resistance has not been studied

Method used

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  • Application of PBK as ovarian cancer cisplatin-resistant target
  • Application of PBK as ovarian cancer cisplatin-resistant target
  • Application of PBK as ovarian cancer cisplatin-resistant target

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Embodiment Construction

[0033] It should be noted that the following detailed description is exemplary and intended to provide further explanation of the present disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs.

[0034] It should be noted that the terminology used herein is only for describing specific embodiments, and is not intended to limit the exemplary embodiments according to the present disclosure. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural, and it should also be understood that when the terms "comprising" and / or "comprising" are used in this specification, they mean There are features, steps, operations, means, components and / or combinations thereof.

[0035] Explanation of terms:

[0036] PBK detection reagents: including the reagents needed to detect PBK content by common de...

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Abstract

The present disclosure belongs to the field of anti-ovarian cancer drugs, and specifically relates to an application of PDZ-binding kinase as an ovarian cancer cisplatin-resistant target. The relationship between PDZ kinase and ovarian cancer as well as between PDZ kinase and a cisplatin-resistance mechanism in the prior art is not studied. In order to clarify the mechanism of cisplatin resistancein patients with ovarian cancer, the invention provide better treatment for patients with ovarian cancer. By aiming at the expression content of PBK and cisplatin-resistance condition of patients with ovarian cancer, the research shows that the high expression of PBK is positively correlated with the poor prognosis of the patients with ovarian cancer, further studies indicate that PBK overexpression promotes autophagy in ovarian cancer cells, and the ovarian cancer cell resistance to cisplatin is induced by promoting autophagy. The application uses a PBK inhibitor in combination with cisplatin for the treatment of ovarian cancer, and the therapeutic effect is superior to that of cisplatin alone.

Description

technical field [0001] The disclosure belongs to the field of anti-ovarian cancer drugs, and specifically relates to the application of PBK as a cisplatin resistance marker of ovarian cancer and the combined use of PBK inhibitors and cisplatin in treating ovarian cancer. Background technique [0002] The information disclosed in this Background section is only intended to increase the understanding of the general background of the disclosure, and is not necessarily to be taken as an acknowledgment or any form of suggestion that the information constitutes prior art that is already known to those skilled in the art. [0003] Malignant ovarian tumor is one of the common malignant tumors of female reproductive organs. The onset of ovarian cancer is hidden. Most patients are diagnosed at an advanced stage, and the five-year survival rate is only about 30%. The annual statistical report of the American Cancer Society shows that in 2019, there will be 22,530 new cases of ovarian c...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P35/00A61K33/243C12Q1/6886
CPCA61K33/24A61K45/00A61P35/00C12Q1/6886C12Q2600/106C12Q2600/118C12Q2600/158A61K2300/00
Inventor 孔北华马汉林苑存忠
Owner SHANDONG UNIV QILU HOSPITAL
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