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Flavonoid compound, pharmaceutically acceptable salt, ester and solvate thereof, and extracting method and application of flavonoid compound

A flavonoid compound, reflux extraction technology, applied in chemical instruments and methods, organic chemistry, pharmaceutical formulations, etc., can solve problems such as environmental pollution and resource waste, achieve good extraction effect, achieve environmental protection, and low solvent toxicity. Effect

Inactive Publication Date: 2019-07-23
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the multiple health functions of camellia oil, the planting area of ​​camellia oleifera is increasing year by year, but the residue (camellia oleifera cake) obtained after oil-pressing of camellia oleifera seeds is the main agricultural by-product. If it is not properly treated, it will cause environmental pollution and waste of resources

Method used

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  • Flavonoid compound, pharmaceutically acceptable salt, ester and solvate thereof, and extracting method and application of flavonoid compound
  • Flavonoid compound, pharmaceutically acceptable salt, ester and solvate thereof, and extracting method and application of flavonoid compound
  • Flavonoid compound, pharmaceutically acceptable salt, ester and solvate thereof, and extracting method and application of flavonoid compound

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Experimental program
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Effect test

Embodiment 1

[0037] The separation and purification of embodiment 1 flavonoids

[0038] (1) Get 25.0Kg of Camellia oleifera cake after degreasing, reflux and extract 3 times with 70% EtOH after pulverization, wherein, Camellia oleifera cake and 70% EtOH mass volume ratio are 1:10g / m, extract 3 hours each time, combine extracting solution, Concentrate under reduced pressure to obtain 6.6Kg Camellia oleifera cake extract.

[0039] (2) The extract is suspended with water, placed in a separatory funnel, extracted 3 times with ethyl acetate equal in volume to the water suspension, then extracted 3 times with n-butanol equal in volume to the water suspension, and recovered After the solvent was removed, 35.0 g of ethyl acetate extract and 858.0 g of n-butanol extract were respectively obtained.

[0040] (3) Ethyl acetate part extract (35.0g) was purified by silica gel column chromatography using EtOAc-CH 3 Gradient elution of OH system (30:1, 20:1, 10:1, 5:1, 1:1) to obtain 5 fractions [E1 (3....

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Abstract

The invention discloses a flavonoid compound with a structure represented by a formula I, an extraction method for extracting the flavonoid compound from oil-tea cakes, and an application of the flavonoid compound in preparation of drugs and products for inhibiting melanin generation and a product. The flavonoid compound structure provided by the invention has a stable structure and a stable drugeffect, and is high in content and purity.

Description

technical field [0001] The present invention relates to the technical field of natural plant extraction, in particular to a flavonoid compound or its pharmaceutically acceptable salt, ester or solvate and its extraction method from camellia oleifera cake and its use in the preparation of medicines and products for inhibiting melanin production . Background technique [0002] Camellia oleifera (Camellia oleifera Abel.) is an evergreen small tree of the genus Camellia Linn in the family Theaceae. It is mainly distributed in China, Japan, and Southeast Asia, covering 18 provinces and regions in my country, including Hunan, Jiangxi, Guangxi, Zhejiang, etc. Province is the main production area. Camellia oleifera is named for its seeds that can extract oil (tea oil). Camellia oil is one of the four major woody vegetable oils in the world. The content of unsaturated fatty acids in tea oil is much higher than that of soybean oil, rapeseed oil and peanut oil, and its content can rea...

Claims

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Application Information

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IPC IPC(8): C07H17/07C07H1/08C07D311/30C07D311/40A61P35/00A61K31/7048A61K31/352
CPCC07H17/07C07H1/08C07D311/30C07D311/40A61P35/00
Inventor 张杰冯锋柳文媛曲玮祝婉芳
Owner CHINA PHARM UNIV
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