Application of stigmasterol to preparing gastric cancer treating drugs

A technology for the use of stigmasterol, applied in the field of medical use of stigmasterol, which can solve the problems of poor clinical results and negative impact on the overall health of patients treated with anticancer drugs

Inactive Publication Date: 2019-07-26
NO 1 AUXILARY HOSPITAL NO 4 MILLITARY MEDICAL UNIV P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main treatment for GC is surgical resection, which also includes chemotherapy in non-surgical patients, but the clinical outcome remains poor
Furthermore, the side effects of anticancer agents used to treat GC negatively impact the overall health of these patients

Method used

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  • Application of stigmasterol to preparing gastric cancer treating drugs
  • Application of stigmasterol to preparing gastric cancer treating drugs
  • Application of stigmasterol to preparing gastric cancer treating drugs

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Experimental program
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Embodiment Construction

[0024] Based on the above description of the content of the invention, those skilled in the art can fully apply the present invention, and all the same principles or similar modifications should be considered to be included within the scope of the present invention.

[0025] Human gastric cancer cell line SNU-1 and normal GES-1 cell line were purchased from American Type Culture Collection. Both cell lines were maintained in Dulbecco's modified Eagle's medium containing 10% fetal bovine serum (FBS), antibodies (100 U / mL penicillin and 100 μg / mL streptomycin) and 2 mM glutamine. Incubate cells at 37 °C, 98% humidity and 5% CO 2 cultured in an incubator (Thermo Scientific). Stigmasterol (98% HPLC purity) and all other chemicals were from Sigma-Aldrich Ltd, USA.

[0026] CCK-8 assay: The effect of stigmasterol on the proliferation of SNU-1 cells was studied by CCK8 assay. Cells (5×10 3 ) were seeded in 96-well plates and incubated at 37°C, 5% CO 2 cultivated in the atmospher...

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Abstract

The invention belongs to the field of medical technology and provides application of stigmasterol to preparing gastric cancer treating drugs. The stigmasterol achieves the gastric cancer treating effects by inhibiting proliferation of gastric cancer cells, inducting apoptosis of the gastric cancer cells, enhancing expression of Bax (B-cell lymphoma-2 associated X), reducing expression of Bcl-2 (B-cell lymphoma-2) proteins, inducing cell cycle arrest of the gastric cancer cells, inhibiting migration of the gastric cancer cells and inhibiting (janus kinase / signal transducers and activators of transcription) pathways.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the medical application of stigmasterol. Background technique [0002] Plants are one of the rich sources of medicines, and they have been used to treat diseases. Several drugs currently used to treat human disease are derived from plants. Diseases such as malaria and cancer are being treated with plant-derived compounds. Some plant-derived compounds such as taxanes, podophyllotoxins, etc. are used in the treatment of cancer. The role of plants as factories for the production of bioactive metabolites requires further exploration. About 70% of the world's population relies on plants in one way or another for basic primary health care. Among these metabolites, sterols are one group, and many sterols have been reported to have anticancer, antibacterial, and anti-inflammatory activities. Stigmasterol (Stigmasterol) is a compound that has been proven to have pharmaco...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61P35/00A61P1/00
CPCA61K31/575A61P1/00A61P35/00
Inventor 李霄岳树强杨静悦丁睿张玄王权成杨佩军
Owner NO 1 AUXILARY HOSPITAL NO 4 MILLITARY MEDICAL UNIV P L A
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