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Two-component in-situ injection polyasparagine biomimetic tissue adhesive and preparation method thereof

A technology of polyasparagine and tissue adhesives, which is applied in surgical adhesives, pharmaceutical formulations, surgery, etc., and can solve problems such as low mechanical strength of adhesives, easy deformation of adhesive matrix, and impact on performance. Achieve the effect of facilitating tissue repair, high adhesion, and easy use

Active Publication Date: 2020-05-22
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this polyasparagine powder product has poor water solubility and can only form a viscous solid adhesive after adding water, which has poor fluidity and cannot be injected to achieve in-situ gelation at tissue wounds
On the other hand, there is no chemical crosslinking point between the macromolecular chains of this modified polyasparagine product, and the adhesive matrix is ​​easily deformed and has no resilience, so the mechanical strength of the adhesive itself (matrix) is not high. It will also affect its performance

Method used

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  • Two-component in-situ injection polyasparagine biomimetic tissue adhesive and preparation method thereof
  • Two-component in-situ injection polyasparagine biomimetic tissue adhesive and preparation method thereof
  • Two-component in-situ injection polyasparagine biomimetic tissue adhesive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A two-component in-situ injection polyasparagine biomimetic tissue adhesive, which is composed of two kinds of polyasparagine with different reactive functional groups, namely component one and component two; Polyasparagine PASAM with vinyl, catechol and hydroxyl functional groups (C=C / Dopa / OH), component two is polyasparagine PASAM with mercapto, catechol and hydroxyl functional groups ( SH / Dopa / OH).

[0055] The structural formula of component one PASAM (C=C / Dopa / OH) is:

[0056]

[0057] The structural formula of component two PASAM (SH / Dopa / OH) is:

[0058]

[0059] The preparation method of component one of the two-component in-situ injection type polyasparagine biomimetic tissue adhesive comprises the following steps:

[0060] (1) Preparation of polyasparagine PASAM (C=C / Dopa) containing double bond and catechol functional group: 485mg polysuccinimide (containing 5mmol succinimide unit) was dissolved in 6gN,N- In dimethylformamide, add 2mmol (215mg) 3-but...

Embodiment 2

[0083] A two-component in-situ injection polyasparagine biomimetic tissue adhesive, which is composed of two kinds of polyasparagine with different reactive functional groups, namely component one and component two; Polyasparagine PASAM with vinyl, catechol and hydroxyl functional groups (C=C / Dopa / OH), component two is polyasparagine PASAM with mercapto, catechol and hydroxyl functional groups ( SH / Dopa / OH).

[0084] The structural formula of component one PASAM (C=C / Dopa / OH) is:

[0085]

[0086] The structural formula of component two PASAM (SH / Dopa / OH) is:

[0087]

[0088] The preparation method of component one of the two-component in-situ injection type polyasparagine biomimetic tissue adhesive comprises the following steps:

[0089] (1) Preparation of polyasparagine PASAM (C=C / Dopa) containing double bond and catechol functional group: 970mg polysuccinimide (containing 10mmol succinimide unit) was dissolved in 10g dimethyl sulfoxide, and added 4mmol (341mg) 4-p...

Embodiment 3

[0102] A two-component in-situ injection polyasparagine biomimetic tissue adhesive, which is composed of two kinds of polyasparagine with different reactive functional groups, namely component one and component two; Polyasparagine PASAM with vinyl, catechol and hydroxyl functional groups (C=C / Dopa / OH), component two is polyasparagine PASAM with mercapto, catechol and hydroxyl functional groups ( SH / Dopa / OH).

[0103] The structural formula of component one PASAM (C=C / Dopa / OH) is:

[0104]

[0105] The structural formula of component two PASAM (SH / Dopa / OH) is:

[0106]

[0107] The preparation method of component one of the two-component in-situ injection type polyasparagine biomimetic tissue adhesive comprises the following steps:

[0108] (1) Preparation of polyasparagine PASAM (C=C / Dopa) containing double bond and catechol functional group: 1455mg polysuccinimide (containing 15mmol succinimide unit) was dissolved in 15g dimethyl In sulfoxide, add 6mmol (561mg) allyl...

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Abstract

The invention discloses a dual-component in-situ injection type polyasparagine bionic tissue adhesive and a preparing method thereof. The tissue adhesive is composed of a first polyasparagine component solution and a second polyasparagine component solution with different reactive functional groups. A first component is polyasparagine with a vinyl functional group, a catechol functional group anda hydroxyl functional group, a second component is polyasparagine with a sulfydryl functional group, a catechol functional group and a hydroxyl functional group, a solvent of the first component is ahydrogen peroxide solution, and a solvent of the second component is a horse radish peroxidase solution. The catechol functional groups in the first component and the second component have the marinemussel imitation adhesion characteristic and can have noncovalent interaction with a tissue surface, the adhesive has tissue adhesiveness, and tissue repairing is realized. The tissue adhesive has excellent tissue adhesive strength and use convenience and has important significance in replacing surgical sutures and healing wounds.

Description

technical field [0001] The invention relates to a tissue adhesive, in particular to a cross-linkable two-component in-situ injection type polyasparagine bionic tissue adhesive, which belongs to the technical field of biomaterials. Background technique [0002] Wound healing is an important issue in the process of wound treatment. The tissue connector used must closely contact the edge of the injured tissue, and must have the function of resisting tissue pulling force and preventing biological fluid leakage, so as to promote wound healing. At present, mechanically invasive techniques are commonly used clinically to promote wound healing, such as surgical sutures, medical staplers, etc. These methods have problems such as cumbersome operations, high bacterial infection rates, and tissue immune responses, which will lead to slow wound healing, and even Threatening the patient's life. [0003] Tissue adhesive is a medical material used for wound hemostasis, healing, and prevent...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/04A61L24/00C08G73/10
CPCA61L24/001A61L24/0031A61L24/046A61L2400/06C08G73/1092C08L77/04
Inventor 李光吉邓俊杰李志豪熊博隋维伟
Owner SOUTH CHINA UNIV OF TECH
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