Method for preparing gentianine injection by taking gentian as raw material and application of method

A technology for gentianine and injection, applied in the field of preparing gentianine injection, can solve problems such as poor solubility of gentianine, and achieve the effects of improving solubility, improving stability and relieving resource pressure
CN110123744AInactive Publication Date: 2019-08-16QIQIHAR MEDICAL UNIVERSITY +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
QIQIHAR MEDICAL UNIVERSITY
Publication Date
2019-08-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a gentianine injection which can be used for anticonvulsant and has a brain protection effect. The injection consists of the following components: 5-10 parts of gentianine crystal powder, 6-15 parts of co-solvents, 1-5 parts of antioxidants, 50-120 parts of osmotic pressure regulators and 1,000 parts of water. The preparation process of the injection is characterized in that ascorbic acid or tartaric acid is used as a cosolvent, which can improve the solubility of the gentianine and effectively improve the stability of the gentianine. From the perspective of pathological sections (ultrastructural changes, organelle changes) research shows that the gentianine does have a definite brain injury protection effect.
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Description

technical field

[0001] The invention relates to the field of medicine preparation, in particular to a method for preparing gentianine injection using gentiana as a raw material and an application thereof. Background technique

[0002] Febrile convulsions, also known as febrile convulsions, are the most common convulsive diseases in children. Frequent or prolonged febrile convulsions can cause central nervous system damage in infants and young children, and affect long-term susceptibility to convulsions and learning and memory functions. . At present, there is still a lack of ideal therapeutic drugs for febrile convulsions: diazepam is the first choice for anticonvulsants, but it is difficult to completely control convulsions with one dose, and repeated use can easily lead to respiratory depression, accompanied by dependence and withdrawal symptoms. Phenobarbital sodium has a long action time and few side effects, and the combination of the two can learn from each other, but...

Claims

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