Method for preparing gentianine injection by taking gentian as raw material and application of method

A technology for gentianine and injection, applied in the field of preparing gentianine injection, can solve problems such as poor solubility of gentianine, and achieve the effects of improving solubility, improving stability and relieving resource pressure

Inactive Publication Date: 2019-08-16
QIQIHAR MEDICAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The poor solubility of gentianine is an important factor restricting clinical drug administration, and how to improve its solubility to facilitate drug administration needs to be solved urgently

Method used

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  • Method for preparing gentianine injection by taking gentian as raw material and application of method
  • Method for preparing gentianine injection by taking gentian as raw material and application of method
  • Method for preparing gentianine injection by taking gentian as raw material and application of method

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Embodiment 1

[0041] gentian 10kg, the gentian medicinal material is produced in Liaoning Province, and purchased from Harbin Tianyuan Medicinal Material Company. The roots and rhizomes of Gentiana (Gentiana scabra Bge.) identified as genuine, the quality conforms to the relevant regulations of the Pharmacopoeia of the People's Republic of China.

[0042] High-performance liquid chromatography (Waters2695-2998 type); ODSC18 chromatographic column (250mm×4.6mm); constant temperature water bath (Beijing Medical Equipment Factory); electronic thermostat heating mantle (Tianjin Test Instrument Co., Ltd.); Evaporator (RE-5298A type, Shanghai Yarong Biochemical Instrument Factory); circulating water vacuum pump (Zhengzhou Great Wall Technology Industry and Trade Co., Ltd.); SHB-3 dual-frequency numerical control ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.); vacuum drying device (DZF-6050, Shanghai Yiheng Technology Instrument Co., Ltd.); four-purpose UV analyzer (ZF-II, Shanghai G...

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Abstract

The invention discloses a gentianine injection which can be used for anticonvulsant and has a brain protection effect. The injection consists of the following components: 5-10 parts of gentianine crystal powder, 6-15 parts of co-solvents, 1-5 parts of antioxidants, 50-120 parts of osmotic pressure regulators and 1,000 parts of water. The preparation process of the injection is characterized in that ascorbic acid or tartaric acid is used as a cosolvent, which can improve the solubility of the gentianine and effectively improve the stability of the gentianine. From the perspective of pathological sections (ultrastructural changes, organelle changes) research shows that the gentianine does have a definite brain injury protection effect.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a method for preparing gentianine injection using gentiana as a raw material and an application thereof. Background technique [0002] Febrile convulsions, also known as febrile convulsions, are the most common convulsive diseases in children. Frequent or prolonged febrile convulsions can cause central nervous system damage in infants and young children, and affect long-term susceptibility to convulsions and learning and memory functions. . At present, there is still a lack of ideal therapeutic drugs for febrile convulsions: diazepam is the first choice for anticonvulsants, but it is difficult to completely control convulsions with one dose, and repeated use can easily lead to respiratory depression, accompanied by dependence and withdrawal symptoms. Phenobarbital sodium has a long action time and few side effects, and the combination of the two can learn from each other, but...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/22A61K47/12A61K31/436A61K36/515A61P25/08A61P25/00C07D491/052
CPCA61K9/0019A61K9/08A61K31/436A61K36/515A61K47/12A61K47/22A61P25/00A61P25/08C07D491/052
Inventor 刘学伟汪娜
Owner QIQIHAR MEDICAL UNIVERSITY
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