A kind of nano metal organic framework cavitation material, synthesis method and application

An organic framework and nano-metal technology, which is applied in the direction of medical preparations containing active ingredients, splitting materials, wave energy or particle radiation treatment materials, etc., can solve the problem of poor solubility of active ingredients and the accumulation rate of tumor sites in long-term circulation It can reduce the amount of drugs used, improve the curative effect of tumor treatment, and achieve the effect of excellent imaging effect.

Active Publication Date: 2021-02-19
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Aiming at the problems that the active ingredients of the existing cavitation agents have poor solubility, it is difficult to achieve long-term circulation in the blood, and the enrichment rate at the tumor site is not high, which makes cavitation therapy difficult to achieve the desired therapeutic effect. The present invention provides A nano-metal-organic framework cavitation material and a preparation method of the material. The metal-organic framework material and a cavitation agent are used to form a composite, which not only improves the water solubility of the active ingredient of the cavitation agent, but also improves the enrichment at the tumor site, and improves Effects of cavitation therapy

Method used

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  • A kind of nano metal organic framework cavitation material, synthesis method and application
  • A kind of nano metal organic framework cavitation material, synthesis method and application
  • A kind of nano metal organic framework cavitation material, synthesis method and application

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Effect test

Embodiment 1

[0036] The preparation steps of the nano metal organic framework cavitation material in this example are as follows:

[0037] 1) using methanol as a solvent, preparing a zirconium chloride solution with a molar concentration of 20mmol / L as the metal source mother liquor; in addition using methanol as a solvent, preparing a terephthalic acid methanol solution with a molar concentration of 40mmol / L as the organic ligand mother liquor;

[0038] 2) Take 10mL each of the metal source mother liquor and the organic ligand mother liquor, mix them evenly, and place them in a 50mL reactor. The molar ratio of the metal source to the organic ligand in the mixed liquor is 1:2; After reacting in an oven at 50°C for 24 hours, take it out, centrifuge and dry to obtain a dry product;

[0039]3) According to the mass ratio of 1:3, weigh the perfluorohexane and the dried product successively in a dry Erlenmeyer flask, add an equal volume of dichloromethane, (the volume ratio of the added volume ...

Embodiment 2

[0041] The preparation steps of the nano metal organic framework cavitation material in this example are as follows:

[0042] 1) Using N,N-dimethylformamide solution as a solvent, prepare a ferric chloride solution with a molar concentration of 10mmol / L as the metal source mother liquor; also use N,N-dimethylformamide solution as a solvent to prepare The p-tetrakis (4-carboxyphenyl) porphin with a molar concentration of 30mmol / L is used as the organic ligand mother liquor;

[0043] 2) Take 10 mL each of the metal source mother liquid and the organic ligand mother liquid, and mix them uniformly and place them in a 50 mL reaction kettle. The molar concentration ratio of the metal source mother liquid and the organic ligand mother liquid in the mixed liquid is 1:3; The reaction kettle was placed in an oven at 90°C for 24 hours and then taken out, centrifuged and dried to obtain a dry product;

[0044] 3) Weigh 1,1,1,3,3-pentafluorobutane and the dried product sequentially accord...

Embodiment 3

[0050] The preparation steps of the nano metal organic framework cavitation material in this example are as follows:

[0051] 1) Using ethanol as a solvent, preparing a zirconium chloride solution with a molar concentration of 10mmol / L as the metal source mother liquor, and also using ethanol as a solvent, preparing a trimesic acid ethanol solution with a molar concentration of 20mmol / L as the organic ligand mother liquor;

[0052] 2) Take 20mL of the metal source mother liquor and the organic ligand mother liquor respectively, mix them uniformly and place them in a 100mL reactor, the molar concentration ratio of the metal source mother liquor and the organic ligand mother liquor in the mixed liquor is 1:2; The reaction kettle was placed in an oven at 70°C for 12 hours and then taken out, centrifuged and dried to obtain a dry product;

[0053] 3) Weigh the perfluorobutane and the dried product sequentially according to the mass ratio of 1:4 in a dry Erlenmeyer flask, add an eq...

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Abstract

The invention discloses a nano metal organic frame cavitation material, a synthesis method and an application thereof, and belongs to the field of ultrasonic cavitation materials. The material uses a nano-metal organic framework as a carrier, and a cavitating agent active component as a load. The preparation method of the material includes the following steps: 1) dissolving the metal source and the organic ligand in a solvent, respectively, to obtain metal source mother liquor and organic ligand mother liquor; 2) mixing the metal source mother liquor and organic ligand mother liquor obtained in step 1) according to the ratio, performing heating reaction, centrifugal separation, and drying to obtain a dry product; 3) combining the obtained dry product with The active components of the cavitating agent are dispersed in the solvent, centrifuged and dried after stirring. Compared with the lipid bubbles used in the prior art, the nano metal organic framework cavitation material of the present invention can significantly improve the stability, prolong the circulation time in the body, increase the enrichment rate of the material in the tumor site, and improve the Treatment efficacy.

Description

technical field [0001] The invention belongs to the field of ultrasonic cavitation materials, and in particular relates to a nanometer metal organic framework cavitation material, a synthesis method and an application. Background technique [0002] At present, nanocarrier technology has been widely used in the field of biomedicine. Due to the rapid growth and abnormal vasculature of tumors, nanocarriers can accumulate at tumor sites through the penetration and retention (EPR) effect. The main bottleneck is to increase the enrichment rate at the tumor site, and the accumulation analysis of tumors shows that only a small part of the injected nanocarriers can reach the tumor tissue (about 0.7%). Furthermore, there has been no significant improvement in this parameter over the past few decades. Tumors in different patients or in different regions of the same patient will also cause uneven distribution of nanocarriers in the tumor due to tumor heterogeneity. In addition, higher...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K49/22A61P35/00C08G83/00
CPCA61K41/0033A61K49/223A61P35/00C08G83/008
Inventor 黄品同张涛
Owner ZHEJIANG UNIV
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