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Rapid detection analysis method for statin drugs in water body

An analytical method and statin technology are applied in the detection and analysis of organic pollutants of drugs in water bodies, and the detection and analysis of organic pollutants of lipid-lowering drugs in water bodies, which can solve the problems of high cost and complicated process, and achieve high repeatability and results. Accurate, wide-ranging effects

Inactive Publication Date: 2019-08-16
SHANGHAI UNIV
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  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the problems of the prior art, the object of the present invention is to overcome the deficiencies of the prior art, provide a rapid detection and analysis method for statins in water, and perform pretreatment in environmental water to improve the process of the existing treatment method Complex and costly technical issues

Method used

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  • Rapid detection analysis method for statin drugs in water body
  • Rapid detection analysis method for statin drugs in water body

Examples

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Embodiment 1

[0022] In this example, see figure 1 , establish the standard curve of target pollutant atorvastatin, take concentration as abscissa, take peak area as ordinate; obtain the standard curve equation of atorvastatin as y=2266.7x-6431, correlation coefficient is that R2 is 0.9995 . Continue to draw the standard curves for rosuvastatin, pravastatin, simvastatin and lovastatin using the same method as for establishing the standard curve for the target pollutant atorvastatin.

Embodiment 2

[0024] In the present embodiment, 5 parts of water samples in the environment were randomly collected, and the standard curve diagrams of atorvastatin, rosuvastatin, pravastatin, simvastatin and lovastatin were drawn using the method in Example 1, and The solid phase extraction method is used for purification and enrichment, and then the actual concentration of the target substance in the sample is analyzed and detected by the method of high performance liquid chromatography-mass spectrometry.

[0025] The solid phase extraction cartridge used in this example is an Oasis HLB cartridge from Waters Company. Liquid chromatography-mass spectrometer model is Agilent 1260 liquid chromatograph, and the chromatographic column is Poroshell 120EC-C18 reverse-phase column (3×100mm, 2.7μm, Agilent).

[0026] In this embodiment, a rapid detection and analysis method for statins in water, comprising the following steps:

[0027] a. Sample pretreatment:

[0028] Randomly collect 5 water sa...

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Abstract

The invention discloses a rapid detection analysis method for statin drugs in a water body, and belongs to the trace detection field of organic pollutants in the water body. In the method for detecting statin substances of lipid-lowering drugs, a solid-phase extraction small column is combined with a high performance liquid chromatography-mass spectrum method, and various statin drugs in the waterbody can be detected efficiently and quickly simultaneously. The method comprises the following steps: filtering a water sample, and adding an internal standard substance; then using the solid-phaseextraction small column to extract and purify the statin substances in the sample; and then detecting the content of a target object in the water sample through a liquid chromatogram-mass spectrometer. The method is simple in treatment steps for the water sample, convenient in operation and high in stability, and the sample applicable for the liquid chromatograph / mass spectrometer can be obtainedquickly; the pretreatment cost of the sample is low, rapid and efficient detection can be carried out, and the method is high in detection speed, high in degree of automation, sensitive in response and convenient for industrial application, is a simple, convenient, rapid and accurate qualitative and quantitative detection method, and is applicable for popularization and application.

Description

technical field [0001] The invention relates to a method for detecting and analyzing organic pollutants of drugs in water bodies, in particular to a method for detecting and analyzing organic pollutants of lipid-lowering drugs in water bodies, which is applied to the technical field of trace detection of organic pollutants in water bodies. Background technique [0002] Statins are a class of drugs used to lower cholesterol levels in the blood, and they are usually prescribed to patients with, or at risk of, coronary heart disease. With the arrival of population aging, statins are being used more and more as lipid-lowering drugs, and statins also occupy more than 80% of the market share in the market of blood lipid-lowering drugs, of which simvastatin, suvastatin, Atorvastatin has become the most used lipid-lowering drug. Statins are continuously released into water bodies through domestic sewage. Due to poor removal efficiency, statins will exist even in water treated by dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/08G01N30/14
CPCG01N30/02G01N30/06G01N30/08G01N30/14G01N2030/045G01N2030/062
Inventor 胡建成姚萃王云江杨诚朱峰
Owner SHANGHAI UNIV
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