Method for researching brain default mode network by using digital map
A technology of default mode and map, applied in image analysis, image enhancement, image data processing, etc., can solve the problems of unstable area of interest delineation, abnormal connection of default network functions, etc.
Active Publication Date: 2019-08-16
SHENZHEN INST OF ADVANCED TECH
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[0003]Since the default mode network DMN has gained great attention in neuroimaging research, more and more studies have shown that the default mode network DMN is associated with various brain abnormalities For example, by resting-state functional magnetic resonance imaging, it can be found that the functional connectivity of the default network in patients with Alzheimer's disease is abnormal: the functional connectivity of the posterior default network is reduced and the functional connectivity of the anterior default network is enhanced, and mild cognitive impairment Cognitive dysfunction (mild cognitive impairment) has also been confirmed to have abnormalities of partial connection enhancement or decline; therefore, the default mode network is just a biomarker for preclinical early diagnosis of some brain cognitive and mental diseases; and existing research Most of the techniques are based on the recognized results to outline the region of interest, and then calculate the functional connection and the relationship between the brain in the resting state and the task state. The shape drawn by the brain area is inconsistent, and the outline of the region of interest is often unstable
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[0045] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.
[0046] It should be noted that, in the case of no conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other.
[0047] The brain map (atlas) is usually a standardized and unified template, which is often used as a reference for the anatomical positioning of the brain structure, a normalized reference for the shape and direction of the brain (for unification to a standard space, such as MNI space) and brain regions For the reference of division, since the latter two cases are usually implemented by computer means, the form of definition is ...
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The invention relates to the technical field of computer image and signal processing, in particular to a method for researching a brain default mode network by using a digital map. The method comprises the following steps: preprocessing a resting-state functional magnetic resonance image, synthesizing a digital map, and calculating a correlation coefficient between a signal time sequence of a region of interest and the region; and taking synthesis of a brain map as a means for enriching region-of-interest division, and exploring the brain area involved in default mode network activation in a computer digital map mode. For the method for researching a brain default mode network by using a digital map, a processized and step-specific processing mode is provided, and the brain area of the default mode network is explored in a computerized mode, and the default mode network is explored through whole brain connection data.
Description
technical field [0001] The invention relates to the technical field of computer image and signal processing, in particular to a method for studying brain default mode network by using digital atlas. Background technique [0002] The concept of the "default mode" of brain function began at the beginning of this century and was proposed by Raichle et al. in 2001. The Default Mode Network, or DMN for short, describes the functional connections of the brain in a resting state. Before the brain focuses on certain new tasks, this structure will always be in a continuous activation state; when there are external stimuli, or When in a routine task, the default mode network is in a deactivated state (inhibited state); therefore, when the brain leaves the purposeful task (Task) state, the area with higher metabolic activity is the default mode network. At present, the research on the default mode network is mainly carried out in two ways: 1. Functional magnetic resonance images, comp...
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IPC IPC(8): G06T7/00G06T5/00
CPCG06T7/0012G06T2207/10088G06T2207/30016G06T5/80G06T5/70
Inventor 李兆祺周家秀张慧玲张海山魏彦杰冯圣中
Owner SHENZHEN INST OF ADVANCED TECH