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Coating agent and medical instrument surface-treated with said coating agent

A technology of medical equipment and coating agent, applied in the field of medical equipment

Active Publication Date: 2019-08-23
TERUMO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, injections cause a lot of pain to patients and healthy people due to pain during puncture and uncomfortable feeling when injecting liquid medicine.

Method used

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  • Coating agent and medical instrument surface-treated with said coating agent
  • Coating agent and medical instrument surface-treated with said coating agent
  • Coating agent and medical instrument surface-treated with said coating agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0166] The effects of the present invention will be described using the following examples and comparative examples. However, the technical scope of the present invention is not limited to the following examples. It should be noted that, in the following examples, unless otherwise specified, the operation was performed at room temperature (25° C.). In addition, unless otherwise specified, "%" and "part" mean "mass%" and "mass part", respectively.

Synthetic example 1

[0167] (Synthesis Example 1: Synthesis of polyorganosiloxane (5) containing amino groups at both ends)

[0168] An amino group-containing polyorganosiloxane (5) having the following structure at both ends was synthesized in the same manner as in Preparation Example 1 of JP-A-7-178159 as follows.

[0169] [chemical formula 13]

[0170] Polyorganosiloxane with amino groups at both ends (5)

[0171]

[0172] In the above structure, x=12000

[0173]That is, 390 parts by mass of toluene was added to 100 parts by mass of polydimethylsiloxane (weight average molecular weight = about 900,000) having silanol groups at both ends of the following structure, and after stirring at 50°C for 3 hours, 20 parts by mass Parts of γ-[N-(β-aminoethyl)amino]propylmethyldimethoxysilane were reacted at 80°C for 12 hours to obtain polyorganosiloxane (5) (heavy Average molecular weight = about 900,000).

[0174] [chemical formula 14]

[0175] Polydimethylsiloxane with silanol groups at both end...

Embodiment 1

[0188] Polydimethylsiloxane (1) (weight-average molecular weight = about 592,000, m in general formula (1) = 8,000) having the following structure and Polydimethylsiloxane (2) (weight average molecular weight = about 3,000, n = 38 in general formula (2)), amino group-containing polyorganosiloxane (3) of the following structure (weight average molecular weight = About 15,000), toluene and ethanol were stirred and mixed at 45° C. for 4 hours to obtain a coating agent 1 (Example 1). It should be noted that in Table 1 below, polydimethylsiloxane (1) is referred to as "compound 1", and polydimethylsiloxane (2) is referred to as "compound 2", The amino group-containing polyorganosiloxane (3) is referred to as "Compound 3".

[0189] [chemical formula 16]

[0190] Dimethicone (1)

[0191]

[0192] Dimethicone (2)

[0193]

[0194] Amino polyorganosiloxane(3)

[0195]

[0196] Wherein, q=5, p:q (molar ratio)=40:1

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Abstract

A coating agent comprises: a polyorganosiloxane (1), which is represented by general formula (1); a polydiorganosiloxane (2), which is represented by general formula (2); an amino-group-containing polyorganosiloxane (3), which is represented by general formula (3); and a hydroxy-group-containing polyorganosiloxane (4), which is represented by general formula (4). The present invention provides a coating agent having improved piercing properties, and a medical instrument (in particular, a needle) surface-treated (coated) with the coating agent.

Description

technical field [0001] The invention relates to a coating agent and a medical device formed by using the coating agent for surface treatment. Background technique [0002] Currently, not only patients with diseases, but also healthy people undergo various medical procedures such as physical examinations. For example, injections are given to patients suffering from diseases for the purpose of infusion of medical solutions for treatment, anesthesia during surgery, and the like. In addition, even healthy people often undergo injections, such as blood donation and vaccination. However, injections cause a lot of pain to patients and healthy people due to the pain during puncture and the uncomfortable feeling when injecting the liquid medicine. Therefore, in order to alleviate the pain, various studies have been conducted on the shape of the tip of the injection needle, the coating agent applied to the surface of the injection needle, and the like. Among them, silicone is mainl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09D183/04A61L31/10A61M5/162A61M5/32C09D183/06C09D183/08
CPCA61L31/10A61M5/162A61M5/32C09D183/04C09D183/08C08G77/16C08G77/26C08L83/00C08L83/04C10M107/50C10M177/00C10M2229/0415C10M2229/0525C10N2040/50C10N2050/08
Inventor 谷田部辉幸
Owner TERUMO KK