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Antidepressant pharmaceutical composition containing adenosine A1 receptor agonist

A technology of receptor agonist and composition, which is applied in the field of antidepressant drug composition, can solve the problems of long onset time, unsatisfactory effect, and many side effects, and achieve fast onset time, small side effects, and definite therapeutic effect Effect

Pending Publication Date: 2019-08-27
PEKING UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the mechanism of action of almost all antidepressants mainly involves the transmission of monoamine neurotransmitters, relatively many side effects, clear curative effect, but not satisfactory, for example, some patients are ineffective to almost all antidepressants, almost all antidepressants The onset time of depression drugs is relatively long, and it takes at least 2 weeks to take effect, etc.

Method used

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  • Antidepressant pharmaceutical composition containing adenosine A1 receptor agonist
  • Antidepressant pharmaceutical composition containing adenosine A1 receptor agonist
  • Antidepressant pharmaceutical composition containing adenosine A1 receptor agonist

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Experimental program
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Embodiment approach

[0032] As mentioned above, the mechanism of action of almost all antidepressants mainly involves the transmission of monoamine neurotransmitters, relatively many side effects, clear curative effect, but not satisfactory, and some patients are ineffective for almost all antidepressants , almost all antidepressants have a relatively long onset time, and it takes at least 2 weeks to take effect. In view of this, the present inventors conducted extensive research on antidepressants.

[0033] The inventors have found that the adenosine A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA) has better antidepressant activity, and the adenosine A1 receptor agonist of a certain amount and concentration is used for For the treatment of depression, the onset of action is fast, the therapeutic effect is definite and significant, and the side effects are small. The present invention has been made based on the above findings.

[0034] Therefore, the antidepressant pharmaceutical com...

Embodiment 1

[0073] Example 1: Effect of 2-chloro-N6-cyclopentyladenosine (CCPA) in antidepressant

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Abstract

The invention relates to an antidepressant pharmaceutical composition containing an adenosine A1 receptor agonist and application thereof. The antidepressant pharmaceutical composition has antidepressant properties, and has the advantages of fast onset time, definite and significant therapeutic effect, and small side effect, and has great application value in treating depression.

Description

technical field [0001] The invention belongs to the technical field of antidepressants, and relates to an antidepressant composition containing an adenosine A1 receptor agonist and an application thereof. Background technique [0002] Depression, also known as depressive disorder, is the main type of mood disorder with significant and persistent low mood as the main clinical feature. It can be seen clinically that the mood is not commensurate with the situation. The emotional depression can range from gloomy to distraught, even pessimistic and world-weary. There may be suicide attempts or behaviors; even stupor; some cases have obvious anxiety and motor agitation; severe cases may Psychotic symptoms such as hallucinations and delusions appear. Each attack lasts for at least 2 weeks, or even several years in the elderly. Most cases have a tendency to recur. Most of each attack can be relieved, and some may have residual symptoms or become chronic. [0003] Antidepressive dr...

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Application Information

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IPC IPC(8): A61K31/7076A61P25/24
CPCA61K31/7076A61P25/24A61K2300/00
Inventor 李素霞王新玲陆林高福时杰
Owner PEKING UNIV