A kind of naphthalene sulfonamide compound, preparation method and application

A naphthalene sulfonamide and compound technology, applied in the field of medicinal chemistry, can solve the problems of poor cell activity, reduced molecular polar surface area, unfavorable membrane penetration, etc.
CN110256305BActive Publication Date: 2020-05-26CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2020-05-26

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Abstract

The invention discloses a naphthalene sulfonamide compound, a preparation method and an application. The naphthalenesulfonamide compounds provided by the present invention can interfere with the combination of Keap1-Nrf2 and activate Nrf2, thereby reducing inflammatory damage, improving the inflammatory microenvironment, having potential anti-inflammatory activity, and can be used to prepare anti-inflammatory drugs for many inflammation-related diseases Inflammatory damage in diseases such as chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, intestinal inflammation, rheumatoid arthritis, etc. .
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Description

technical field

[0001] The invention belongs to the field of medicinal chemistry, and in particular relates to a naphthalenesulfonamide compound, a preparation method and an application. Background technique

[0002] Oxygen (O 2 ) are essential for cellular energy metabolism and living systems, but reactive oxygen species (ROS) are generated during these metabolic processes, and ROS play a major role in the initiation and progression of cancer, inflammatory diseases, and neurodegenerative diseases. The antioxidant defense system consisting of detoxifying and antioxidant enzymes can attenuate the damaging effects of ROS, such as superoxide dismutase (SOD), glutathione catalase (GPx), thioredoxin, HO-1 , ferritin, glutathione reductase, NAD(P)H dehydrogenase (NQO1) and glutathione S-transferase (GST). Antioxidant enzymes are regulated by antioxidant response elements (AREs), and nuclear factor E2-related factor 2 (Nrf2) is one of the major ARE-binding transcription factors. ...

Claims

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