Application of acanthopanax senticosus extract in preparing medicine for preventing or treating cardiac toxicity

An Acanthopanax senticosus extract and cardiotoxicity technology, applied in the field of medicine, can solve problems such as changes, clinical application limitations, cardiotoxic effects, etc., and achieve the effects of avoiding side effects, reducing oxidative and inflammatory damage, and increasing myocardial function.

Inactive Publication Date: 2018-09-11
HARBIN ZHENBAO PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, doxorubicin has a high affinity to myocardial tissue and has serious cardiotoxicity, mainly manifested as myocarditis, cardiomyopathy, increased heart rate, and various arrhythmias in the early stage of medication, and dose-dependent chronic heart failure CHF and ST in the late stage. segment changes, its case fatality rate can reach 30-50%, so its clinical application is severely limited

Method used

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  • Application of acanthopanax senticosus extract in preparing medicine for preventing or treating cardiac toxicity
  • Application of acanthopanax senticosus extract in preparing medicine for preventing or treating cardiac toxicity
  • Application of acanthopanax senticosus extract in preparing medicine for preventing or treating cardiac toxicity

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Experimental program
Comparison scheme
Effect test

Embodiment

[0026] Below in conjunction with animal test, the new application of the Acanthopanax senticosus extract proposed by the present invention is described:

[0027] 1. Test materials

[0028] 1.1 Drugs and reagents

[0029] 1.1.1 Test drug

[0030] Acanthopanax extract is Acanthopanax injection, which is produced by Harbin Zhenbao Pharmaceutical Co., Ltd., and the specification is 20ml / bottle. Before use, it is prepared to the required concentration with physiological saline solution for intravenous administration.

[0031] 1.1.2 Positive control drug

[0032] Shenqi Fuzheng Injection, produced by Limin Pharmaceutical Factory of Livzon Group, the specification is 250ml / bottle, batch number 160617. Before use, it is prepared to the required concentration with physiological saline solution for intravenous administration.

[0033] Diazepam injection, produced by Tianjin Jinyao Pharmaceutical Co., Ltd., the specification is 10mg / 2ml / bottle, and the batch number is 1609191. Befo...

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Abstract

The invention provides an application of an acanthopanax extract in preparing medicine for preventing or treating cardiac toxicity, and belongs to the field of medicine. The inventor finds that the acanthopanacis senticosi extract can effectively prevent or treat cardiac toxicity caused by adriamycin, can increase myocardial function, improve cardiac configuration and cardiac remodeling, alleviatemyocardial tissue ultrastructure and pathological change, and inhibit apoptosis of damaged myocardial cells and reduce oxidative and inflammatory damage of myocardial cells. The extract can be used for preparing medicine for preventing or treating cardiac toxicity, thereby protecting myocardial cells, avoiding side effects of adriamycin and having wide application prospect.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the use of an eleuthero japonicus extract in the preparation of medicines for preventing or treating cardiotoxicity. Background technique [0002] Adriamycin (Doxrubicin, Doxrubicin) belongs to anthracycline drugs, is a commonly used cancer chemotherapy drug in clinical practice, and is widely used in the treatment of various solid tumors and hematologic malignancies. However, doxorubicin has a high affinity to myocardial tissue and has serious cardiotoxicity, mainly manifested as myocarditis, cardiomyopathy, increased heart rate, and various arrhythmias in the early stage of medication, and dose-dependent chronic heart failure CHF and ST in the late stage. segment changes, its case fatality rate can reach 30-50%, so its clinical application is severely limited. [0003] The exact mechanism of doxorubicin-induced myocardial injury is relatively complex. Recent studies suggest that oxida...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/254A61P9/00
Inventor 方同华许照芹周广红葛一蒙
Owner HARBIN ZHENBAO PHARMA
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