Application of acanthopanax senticosus extract in preparing medicine for preventing or treating cardiac toxicity

An Acanthopanax senticosus extract and cardiotoxicity technology, applied in the field of medicine, can solve problems such as changes, clinical application limitations, cardiotoxic effects, etc., and achieve the effects of avoiding side effects, reducing oxidative and inflammatory damage, and increasing myocardial function.
CN108514567AInactive Publication Date: 2018-09-11HARBIN ZHENBAO PHARMA +1
1 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HARBIN ZHENBAO PHARMA
Publication Date
2018-09-11
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides an application of an acanthopanax extract in preparing medicine for preventing or treating cardiac toxicity, and belongs to the field of medicine. The inventor finds that the acanthopanacis senticosi extract can effectively prevent or treat cardiac toxicity caused by adriamycin, can increase myocardial function, improve cardiac configuration and cardiac remodeling, alleviatemyocardial tissue ultrastructure and pathological change, and inhibit apoptosis of damaged myocardial cells and reduce oxidative and inflammatory damage of myocardial cells. The extract can be used for preparing medicine for preventing or treating cardiac toxicity, thereby protecting myocardial cells, avoiding side effects of adriamycin and having wide application prospect.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of medicines, in particular to the use of an eleuthero japonicus extract in the preparation of medicines for preventing or treating cardiotoxicity. Background technique

[0002] Adriamycin (Doxrubicin, Doxrubicin) belongs to anthracycline drugs, is a commonly used cancer chemotherapy drug in clinical practice, and is widely used in the treatment of various solid tumors and hematologic malignancies. However, doxorubicin has a high affinity to myocardial tissue and has serious cardiotoxicity, mainly manifested as myocarditis, cardiomyopathy, increased heart rate, and various arrhythmias in the early stage of medication, and dose-dependent chronic heart failure CHF and ST in the late stage. segment changes, its case fatality rate can reach 30-50%, so its clinical application is severely limited.

[0003] The exact mechanism of doxorubicin-induced myocardial injury is relatively complex. Recent studies suggest that oxida...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More