3results about How to "Improve myocardial function" patented technology

This invention belongs to the field of medical technology, specifically relating to the application of mitochondrial transplantation to regulate the immune-metabolic network in the treatment of myocardial dysfunction after cardiac arrest. The mitochondrial transplantation is performed within 0.5-2 hours after the restoration of spontaneous cardiac circulation. This technical solution, through multi-omics integrated analysis, proposes that mitochondrial transplantation exerts a cardioprotective effect by regulating the immune-metabolic-mitochondrial triaxial synergistic network, providing a new research direction for the precision treatment of myocardial dysfunction after cardiac arrest.

This invention relates to a myocardial repair patch based on multi-material printing, its preparation, and its application, belonging to the field of bio-3D printing and regenerative medicine technology. The invention uses PLCL and GelMA hydrogel loaded with active cardiomyocytes as bio-inks, and introduces gelatin gel as a heat buffer material. An orthogonal network structure is constructed using multi-material bio-3D printing technology to prepare a myocardial repair patch with excellent dynamic adaptability to the myocardial interface and good biocompatibility. The myocardial injury repair patch prepared by this invention achieves a structure-function integrated design through the synergistic effect of the three materials, significantly overcoming the limitations of single materials in terms of mechanical properties, biological function, or thermal compatibility. The mechanical properties of the myocardial injury repair patch prepared by this invention can precisely match those of natural myocardium, while possessing high cell activity, effectively inhibiting fibrosis, improving myocardial function, and achieving true active repair. Furthermore, the process conditions are controllable, demonstrating good translational potential.

The invention relates to the technical field of heart transplantation and organ preservation, and discloses a donor heart myocardial protection system and method. The system comprises a heart containing unit used for containing a donor heart and a heart preservation solution and enabling the donor heart to suspend in the heart preservation solution; the heat buffering and isolating unit is used for accommodating the heart accommodating unit, a low-temperature buffering medium is arranged in the heat buffering and isolating unit, and the heart accommodating unit is separated from the inner wall of the heat buffering and isolating unit through the low-temperature buffering medium; and the external low-temperature unit is used for accommodating the thermal buffer isolation unit and providing an external low-temperature environment. Through suspension and thermal buffer mechanisms, the space temperature gradient between different parts of the donor heart is effectively reduced, and local supercooling or freezing is avoided. The method is simple, does not depend on complex equipment, and is easy to popularize and apply in the existing clinical cold preservation process.