7results about How to "Improve myocardial function" patented technology

The invention discloses a MaR1 nano-composite and a preparation method and application thereof, and belongs to the technical field of biological medicine, the MaR1 nano-composite comprises a liposome, a targeting peptide, and MaR1 or pharmaceutically acceptable salt thereof entrapped in the liposome. According to the invention, the effective drug MaR1 and the myocardial targeting peptide are connected by adopting lipidosome, and nano precipitation is carried out by using a microfluid mixing channel, so that the nano drug has high bioavailability and stability. The MaR1 nano-liposome drug prepared by the invention has the characteristics of high bioavailability, stable property, quick response, low side effect and the like, and has a remarkable protective effect on myocardial reperfusion injury.

This invention belongs to the field of medical technology, specifically relating to the application of mitochondrial transplantation to regulate the immune-metabolic network in the treatment of myocardial dysfunction after cardiac arrest. The mitochondrial transplantation is performed within 0.5-2 hours after the restoration of spontaneous cardiac circulation. This technical solution, through multi-omics integrated analysis, proposes that mitochondrial transplantation exerts a cardioprotective effect by regulating the immune-metabolic-mitochondrial triaxial synergistic network, providing a new research direction for the precision treatment of myocardial dysfunction after cardiac arrest.

The invention discloses a traditional Chinese medicine composition for improving heart and kidney function decline and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-40 parts of ginseng, 20-40 parts of rabdosia rubescens, 10-30 parts of pseudo-ginseng, 5-25 parts of glossy privet fruit, 5-25 parts of schisandra chinensis and 5-25 parts of cinnamon; the invention further discloses a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition has the beneficial effects that ginseng is used as a monarch drug to tonify qi, tonify heart and enhance cardiac contractility, which is a leading drug of the whole formula; rabdosia rubescens and pseudo-ginseng serve as ministerial drugs, rabdosia rubescens can clear away heat and toxic materials, pseudo-ginseng can promote blood circulation to remove blood stasis, and the ministerial drugs jointly assist the And glossy privet fruit, schisandra chinensis and cinnamon are used as adjuvant drugs to nourish liver and kidney, astringe and induce astringency, warm yang and dredge vessels, and promote the exertion of the efficacy of the whole prescription. All the medicines are combined to comprehensively regulate heart and kidney functions and improve the living quality of patients.

According to the purification method, the yield is increased through a microwave method, and the coenzyme Q10 is matched with 20-30 parts of radix ophiopogonis, 15-25 parts of angelica sinensis, 20-30 parts of codonopsis pilosula, 18-22 parts of astragalus membranaceus, 20-30 parts of ginseng, 5-15 parts of cordyceps sinensis, 20-30 parts of ginger processed pinellia, 18-22 parts of pericarpium citri reticulatae, 15-25 parts of semen lepidii, 20-30 parts of semen brassicae, 30-40 parts of poria cocos, 20-30 parts of rhizoma atractylodis macrocephalae, 15-25 parts of peach kernels, 10-20 parts of safflower carthamus, 15-25 parts of ligusticum wallichii and the like. By tonifying heart qi and lung qi, warming lung and reducing phlegm, removing stasis and diminishing swelling, purging lung and promoting diuresis, tonifying spleen and excreting dampness, eliminating phlegm and resolving fluid retention, and promoting blood circulation and removing blood stasis, the traditional Chinese medicine composition has a good effect on treating the phlegm and fluid retention lung syndrome type heart failure.

The invention discloses a Tibetan type novel beverage capable of preserving health. The Tibetan type novel beverage comprises the following raw materials in parts by weight: 0-5g of cordyceps sinensis, 0-5g of rhodiola rosea, 0-5g of brown sugar, 0-5g of rock candy and 250-750ml of boiling water / milk. The tea has the advantages that the tea is reasonable in raw material design and convenient to prepare, and has the effects of tonifying qi, clearing away lung-heat, benefiting intelligence, nourishing heart, inducing astringency, stopping bleeding, dissipating stasis, diminishing swelling, tonifying kidney, strengthening essence, stopping bleeding, reducing phlegm, enhancing myocardial function, enhancing liver function, improving respiratory system, enhancing kidney function, enriching blood, producing hematopoiesis, inhibiting and resisting cancer, maintaining beauty, keeping young, regulating blood fat and enhancing immunity. The traditional Chinese medicine composition is mainly used for treating qi deficiency and weakness, intolerance of cold after illness, shortness of breath and weakness, cough with lung heat, hemoptysis, leucorrhea diarrhea, traumatic injury and the like, has important pharmacological effects on protection and improvement of organs such as a circulatory system, a respiratory system, a kidney and the like, aging resistance and the like, and has good popularization prospects and economic values.

This invention relates to a myocardial repair patch based on multi-material printing, its preparation, and its application, belonging to the field of bio-3D printing and regenerative medicine technology. The invention uses PLCL and GelMA hydrogel loaded with active cardiomyocytes as bio-inks, and introduces gelatin gel as a heat buffer material. An orthogonal network structure is constructed using multi-material bio-3D printing technology to prepare a myocardial repair patch with excellent dynamic adaptability to the myocardial interface and good biocompatibility. The myocardial injury repair patch prepared by this invention achieves a structure-function integrated design through the synergistic effect of the three materials, significantly overcoming the limitations of single materials in terms of mechanical properties, biological function, or thermal compatibility. The mechanical properties of the myocardial injury repair patch prepared by this invention can precisely match those of natural myocardium, while possessing high cell activity, effectively inhibiting fibrosis, improving myocardial function, and achieving true active repair. Furthermore, the process conditions are controllable, demonstrating good translational potential.

The invention relates to the technical field of heart transplantation and organ preservation, and discloses a donor heart myocardial protection system and method. The system comprises a heart containing unit used for containing a donor heart and a heart preservation solution and enabling the donor heart to suspend in the heart preservation solution; the heat buffering and isolating unit is used for accommodating the heart accommodating unit, a low-temperature buffering medium is arranged in the heat buffering and isolating unit, and the heart accommodating unit is separated from the inner wall of the heat buffering and isolating unit through the low-temperature buffering medium; and the external low-temperature unit is used for accommodating the thermal buffer isolation unit and providing an external low-temperature environment. Through suspension and thermal buffer mechanisms, the space temperature gradient between different parts of the donor heart is effectively reduced, and local supercooling or freezing is avoided. The method is simple, does not depend on complex equipment, and is easy to popularize and apply in the existing clinical cold preservation process.