Method of increasing trafficking of endothelial progenitor cells to ischemia-damaged tissue

a technology of endothelial progenitor cells and trafficking routes, which is applied in the direction of cell culture active agents, peptide/protein ingredients, unknown materials, etc., can solve the problems of ischemic site signals required for chemoattraction of such bone marrow-derived precursors, the receptors used by, and subsequent heart failure and death, so as to reduce the trafficking of endothelial progenitor cells and reduce the ability of progenitor cells
US20080057069A1Inactive Publication Date: 2008-03-06THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
Publication Date
2008-03-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention provides a method of increasing trafficking of endothelial progenitor cells to ischemia-damaged tissue in a subject comprising administering to the subject an agent that inhibits interaction between Stromal-Derived Factor-1 and CXCR-4.
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Description

[0001] This application is a continuation-in-part and claims priority of U.S. Ser. No. 09 / 587,441, filed Jun. 5, 2000, the contents of which are hereby incorporated by reference.

[0002] Throughout this application, various references are referred to within parentheses. Disclosures of these publications in their entireties are hereby incorporated by reference into this application to more fully describe the state of the art to which this invention pertains. Full bibliographic citation for these references may be found at the end of this application, preceding the claims. BACKGROUND OF THE INVENTION

[0003] Left ventricular remodeling after myocardial infarction is a major cause of subsequent heart failure and death. The capillary network cannot keep pace with the greater demands of the hypertrophied but viable myocardium, resulting in myocardial death and fibrous replacement. The first series of experiments of the present invention, described below, show that human adult bone marrow co...

Claims

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