miR-451a antisense strand inhibitor and application thereof

A technology of mir-451a and 3.mir-451a, applied in the field of biomedicine, can solve the problem that the action and mechanism of miR-451a have not yet been reported, and achieve the effect of protecting liver function, reducing alcoholic fatty liver disease and reducing fat accumulation
CN110302209AActive Publication Date: 2019-10-08THE FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIV
Publication Date
2019-10-08

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Abstract

The invention discloses a miR-451a antisense strand inhibitor and an application thereof. According to the invention, a mouse model with alcoholic liver disease is established, deep sequencing of small RNA on the liver tissues of a model group and a normal control group can be performed, the differentially expressed miR-451a can be analyzed and screened, and qRT-PCR is used for verification. the miR-451a antisense strand inhibitor is chemically synthesized, in-vivo experiments in mice is carried out, the results show that the miR-451a antisense strand inhibitor effectively reduces ALT and glutamic-pyruvic transaminase AST in serum of mice with alcoholic fatty liver disease, and the accumulation of fat in the liver is significantly reduced, which indicates that the miR-451a antisense chaininhibitor can protect liver function and alleviate alcoholic fatty liver disease. The miR-451a antisense strand inhibitor is expected to be developed as a new small molecule RNA drug for the treatmentof alcoholic fatty liver disease.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and specifically relates to a miR-451a antisense chain inhibitor and application thereof. Background technique

[0002] Alcoholic fatty liver is a common liver disease in western countries and belongs to a subtype of alcoholic liver disease (alcoholic liver disease, ALD). In recent years, the incidence of alcoholic liver disease in my country has shown an obvious upward trend, and it is often combined with hepatitis virus infection, causing serious harm to people's health. At present, its pathogenesis is not clear, and there is still a lack of effective treatment.

[0003] The liver is the main site of ethanol metabolism. About 90% of the alcohol ingested by the body is metabolized by the liver. Alcohol is mainly metabolized by three enzyme systems in the liver: alcohol dehydrogenase system (ADH), microsomal ethanol oxidation system (MEOS) and peroxidase in peroxisomes. Alcohol inhibits A...

Claims

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