Application of broadleaf holly leaf aqueous extract and drug composition for regulating intestinal microecology
A technology for regulating the intestinal tract and intestinal flora, which is applied in the direction of drug combination, application, food ingredients containing natural extracts, etc., and can solve the problems that the regulation of intestinal flora disorder has not been reported in literature or patent discovery
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preparation example Construction
[0029] In the present invention, the Kudingcha water extract can be prepared by conventional methods. In a specific embodiment, the preparation method of the Kudingcha water extract comprises the following steps:
[0030] S1. Grinding the dried Kuding tea leaves into fine powder, soaking them in water for 30 minutes, adding water according to the volume ratio of Kuding tea leaves and water to 1:10, and decocting at 90-100° C. for 1 hour;
[0031] S2. Collect the decoction obtained in step S1 and filter, add water to decoct the residue obtained in step S1 according to the ratio of residue to water volume ratio of 1:5, decoct at 90-100° C. for 1 hour, combine the filtrate twice, and filter again;
[0032] S3, concentrating the filtrate obtained in step S2 under reduced pressure at 40-60°C and 1.0KPa to form a thick paste;
[0033] S4. Freeze-dry the product obtained in step S3 into powder to obtain Kudingcha water extract.
[0034] In the application of the present invention, ...
preparation example 1
[0042]This preparation example is used to illustrate the preparation process of Kudingcha water extract, and the specific preparation process is:
[0043] S1. Grinding the dried Kuding tea leaves into fine powder, soaking them in water for 30 minutes, adding water according to the volume ratio of Kuding tea leaves and water to 1:10, and decocting at 100° C. for 1 hour;
[0044] S2. Collect the decoction obtained in step S1 and filter, add water to decoct the residue obtained in step S1 according to the ratio of residue to water volume ratio of 1:5, decoct at 100°C for 1 hour, combine the filtrate twice, and filter again;
[0045] S3, concentrating the filtrate obtained in step S2 under reduced pressure at 40°C and 1.0KPa to form a thick paste;
[0046] S4. Freeze-dry the product obtained in step S3 into powder to obtain Kudingcha water extract.
Embodiment 1
[0048] This example is used to illustrate the regulating effect of the water extract of Kudingcha on the body weight of mice with intestinal flora disorder induced by high-fat diet and the inhibitory effect on intestinal inflammation.
[0049] In order to study the regulatory effect of Kudingcha water extract on the body weight of mice with intestinal flora disorder induced by high-fat diet and the inhibitory effect on intestinal inflammation, a mouse model of intestinal flora disorder induced by high-fat diet was established and Drug treatment. Specifically include the following steps:
[0050] (1) Male C57BL / 6 mice aged 4-6 weeks and weighing 20±2g were randomly divided into normal diet group (NCD), high-fat diet group (HFD), normal diet plus Kudingcha group (NCD- KD), high-fat diet plus Kudingcha group (HFD-KD).
[0051] (2) Feeding conditions Maintain suitable temperature and humidity, circadian rhythm, feed normal standard feed and sterile drinking water. After a week ...
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