Application of broadleaf holly leaf aqueous extract and drug composition for regulating intestinal microecology

A technology for regulating the intestinal tract and intestinal flora, which is applied in the direction of drug combination, application, food ingredients containing natural extracts, etc., and can solve the problems that the regulation of intestinal flora disorder has not been reported in literature or patent discovery

Inactive Publication Date: 2020-02-04
HUBEI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Existing studies suggest that Kudingcha may regulate intestinal flora disorder and improve intestinal barrier function, so as to improve obesity, type Ⅱ diabetes, non-alcoholic fatty liver and ot...

Method used

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  • Application of broadleaf holly leaf aqueous extract and drug composition for regulating intestinal microecology
  • Application of broadleaf holly leaf aqueous extract and drug composition for regulating intestinal microecology
  • Application of broadleaf holly leaf aqueous extract and drug composition for regulating intestinal microecology

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preparation example Construction

[0029] In the present invention, the Kudingcha water extract can be prepared by conventional methods. In a specific embodiment, the preparation method of the Kudingcha water extract comprises the following steps:

[0030] S1. Grinding the dried Kuding tea leaves into fine powder, soaking them in water for 30 minutes, adding water according to the volume ratio of Kuding tea leaves and water to 1:10, and decocting at 90-100° C. for 1 hour;

[0031] S2. Collect the decoction obtained in step S1 and filter, add water to decoct the residue obtained in step S1 according to the ratio of residue to water volume ratio of 1:5, decoct at 90-100° C. for 1 hour, combine the filtrate twice, and filter again;

[0032] S3, concentrating the filtrate obtained in step S2 under reduced pressure at 40-60°C and 1.0KPa to form a thick paste;

[0033] S4. Freeze-dry the product obtained in step S3 into powder to obtain Kudingcha water extract.

[0034] In the application of the present invention, ...

preparation example 1

[0042]This preparation example is used to illustrate the preparation process of Kudingcha water extract, and the specific preparation process is:

[0043] S1. Grinding the dried Kuding tea leaves into fine powder, soaking them in water for 30 minutes, adding water according to the volume ratio of Kuding tea leaves and water to 1:10, and decocting at 100° C. for 1 hour;

[0044] S2. Collect the decoction obtained in step S1 and filter, add water to decoct the residue obtained in step S1 according to the ratio of residue to water volume ratio of 1:5, decoct at 100°C for 1 hour, combine the filtrate twice, and filter again;

[0045] S3, concentrating the filtrate obtained in step S2 under reduced pressure at 40°C and 1.0KPa to form a thick paste;

[0046] S4. Freeze-dry the product obtained in step S3 into powder to obtain Kudingcha water extract.

Embodiment 1

[0048] This example is used to illustrate the regulating effect of the water extract of Kudingcha on the body weight of mice with intestinal flora disorder induced by high-fat diet and the inhibitory effect on intestinal inflammation.

[0049] In order to study the regulatory effect of Kudingcha water extract on the body weight of mice with intestinal flora disorder induced by high-fat diet and the inhibitory effect on intestinal inflammation, a mouse model of intestinal flora disorder induced by high-fat diet was established and Drug treatment. Specifically include the following steps:

[0050] (1) Male C57BL / 6 mice aged 4-6 weeks and weighing 20±2g were randomly divided into normal diet group (NCD), high-fat diet group (HFD), normal diet plus Kudingcha group (NCD- KD), high-fat diet plus Kudingcha group (HFD-KD).

[0051] (2) Feeding conditions Maintain suitable temperature and humidity, circadian rhythm, feed normal standard feed and sterile drinking water. After a week ...

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Abstract

The invention relates to technical field of functional food and medical health care, and discloses application of a broadleaf holly leaf aqueous extract and a drug composition for regulating intestinal microecology. The invention provides application of the broadleaf holly leaf aqueous extract to preparation of a drug for regulating the intestinal microecology, and the drug composition for regulating the intestinal microecology. Through animal experiments, the application of the broadleaf holly leaf aqueous extract to regulating of the intestinal microecology is studied, it is found that by improving diversity of mice intestinal flora, the broadleaf holly leaf aqueous extract effectively regulates intestinal flora disturbance and improves the barrier function of the intestinal tract, lowers expression of inflammatory factors of intestinal tissue, promotes secretion of intestinal mucins, and thus achieves the effects of lowering lipid and losing weight, lowering blood glucose and lowering fat accumulation; and it shows that the broadleaf holly leaf aqueous extract can regulate diseases of obesity, type 2 diabetes, non-alcoholic fatty liver disease and the like caused by intestinal flora disturbance.

Description

technical field [0001] The invention relates to the technical fields of functional food and medicine and health care, in particular to the application of Kudingcha water extract and a pharmaceutical composition for regulating intestinal microecology. Background technique [0002] Intestinal microecology refers to a huge ecosystem composed of the host intestine and its adjacent microorganisms. The beneficial bacteria and harmful bacteria in the intestinal micro-ecosystem restrict each other and depend on each other to form a balance in the intestinal micro-ecological system in terms of quality and quantity; once the internal and external environment of the body changes, the beneficial bacteria are inhibited, and the harmful bacteria take the opportunity to reproduce, thus causing Intestinal flora imbalance, pathological manifestations, and a series of clinical symptoms are called intestinal flora disorders. Modern research results show that transplanting fecal bacteria from ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P3/04A61P3/10A61P1/16A23L33/105
CPCA23V2002/00A61K36/185A23L33/105A61P1/16A61P3/04A61P3/10A23V2200/332A23V2200/328A23V2250/21
Inventor 刘洪涛陈嫚杨庆雄郑军平邹小娟胡白飞殷明珠张志刚
Owner HUBEI UNIV OF CHINESE MEDICINE
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