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Recognition method and device of miRNA sponge module

A sponge and gene technology, applied in the field of identification of miRNA sponge modules, can solve the problem of inaccurate miRNA sponge modules

Active Publication Date: 2019-10-11
孙少平
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  • Abstract
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  • Claims
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Problems solved by technology

[0005] The object of the present invention is to provide a method and device for identifying miRNA sponge modules to solve the problem that the identified miRNA sponge modules that exist in the prior art are not accurate enough

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  • Recognition method and device of miRNA sponge module
  • Recognition method and device of miRNA sponge module
  • Recognition method and device of miRNA sponge module

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Embodiment Construction

[0048] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments It is a part of embodiments of the present invention, but not all embodiments. The components of the embodiments of the invention generally described and illustrated in the figures herein may be arranged and designed in a variety of different configurations.

[0049] Accordingly, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art wi...

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Abstract

The invention provides a recognition method and device of a miRNA sponge module. The method comprises the following steps: acquiring an expression matrix of sponge genes and an expression matrix of target genes of a matched sample; obtaining a plurality of sponge gene-target gene co-expression modules according to the expression matrix of the sponge gene and the expression matrix of the target gene; for each sponge gene-target gene co-expression module, obtaining a significance value of the shared miRNA, a typical correlation coefficient between the sponge gene and the target gene and a sensitivity typical correlation coefficient when the miRNA is shared; and determining whether each sponge gene-target gene co-expression module is an miRNA sponge module or not according to the above parameters. According to the scheme, the competitive strength between the sponge gene and the target gene can be measured at the module level, and whether the sponge gene-target gene co-expression module isthe miRNA sponge module or not is determined according to the competitive strength between the sponge gene and the target gene, so that the miRNA sponge module is recognized more accurately.

Description

technical field [0001] The invention relates to the technical field of gene identification, in particular to a method and device for identifying miRNA sponge modules. Background technique [0002] MicroRNA (miRNA) is a kind of non-coding small RNA molecule with an endogenous length of about 21-23 nucleotides. It completes the shearing with messenger RNA (Messenger RNA, mRNA) through the principle of complementary base pairing. , Inhibition of translation and protein degradation processes. Different transcripts that share the same microRNA response elements (miRNA response elements, MREs) and form a competitive relationship are collectively referred to as miRNA sponges. miRNA sponges are not independent but aggregated into clusters or modules to complete their important missions in physiological and pathological processes. Therefore, mining miRNA sponge modules is of great significance for studying human physiological and pathological processes. [0003] In the prior art, ...

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Application Information

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IPC IPC(8): G16B20/00
CPCG16B20/00
Inventor 张俊鹏饶妮妮
Owner 孙少平
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