Application of asparagus extract in preparing medicine for treating inflammation and medicine

A technology of asparagus extract and inflammation, which is applied in the application of medicine and the field of medicine, can solve the problems of reduced vasodilation, enlarged vascular tension, elevated blood pressure, etc., and achieves the effect of inhibiting inflammatory response and reducing inflammation

Inactive Publication Date: 2019-10-15
SHANGHAI ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first is that the function of endothelial cells in hypertensive patients is impaired, because endothelial cells are crucial regulators of vascular tension, and damage to endothelial cells will reduce vasodilation and lead to increased blood pressure; on the other hand, hypertensive patients The body is in a pro-inflammatory and pro-thrombotic state, which increases the tension in blood vessels and increases blood pressure

Method used

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  • Application of asparagus extract in preparing medicine for treating inflammation and medicine
  • Application of asparagus extract in preparing medicine for treating inflammation and medicine
  • Application of asparagus extract in preparing medicine for treating inflammation and medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1, the preparation of asparagus ethanol extract

[0049] The preparation method of asparagus ethanol extract comprises the steps:

[0050] (1), 10g of asparagus was frozen and ground at 4°C to form a homogenate, then added 1000mL of water-ethanol mixture (the volume fraction of ethanol was 75%), and controlled at 45°C for constant temperature extraction for 3 hours;

[0051] (2), step (1) was repeated 3 times, the alcohol extract was combined, and the extract was concentrated by a rotary evaporator at 45°C. After the ethanol was recovered, it was vacuum freeze-dried at a temperature lower than -50°C and a vacuum degree of less than 15Pa. The extract is obtained as a powder, that is, the ethanol extract of asparagus.

Embodiment 2

[0052] Embodiment 2, the preparation of asparagus ethanol extract

[0053] The preparation method of asparagus ethanol extract comprises the steps:

[0054] (1), 10g of asparagus is frozen and ground at 0°C to form a homogenate, then add 1000m of water-ethanol mixture (the volume fraction of ethanol is 50%), and control the leaching at a constant temperature of 45°C for 2 hours;

[0055] (2), step (1) was repeated 4 times, combined the alcohol extracts, concentrated the extracts with a rotary evaporator at 45°C, and vacuum freeze-dried at a temperature lower than -50°C and a vacuum degree of less than 15Pa after recovery of ethanol The extract is obtained as a powder, that is, the ethanol extract of asparagus.

Embodiment 3

[0056] Embodiment 3, the preparation of asparagus ethanol extract

[0057] The preparation method of asparagus ethanol extract comprises the steps:

[0058] (1) 10g of asparagus was frozen and ground at 6°C to form a homogenate, then 500mL of water-ethanol mixture (volume fraction of ethanol was 90%) was added, and extracted at a constant temperature of 50°C for 2 hours;

[0059] (2) Repeat step (1) twice, combine the alcohol extracts, concentrate the extracts with a rotary evaporator at 45°C, and freeze-dry them in vacuum under the condition that the temperature is lower than -50°C and the vacuum degree is less than 15Pa after the ethanol is recovered. The extract is obtained as a powder, that is, the ethanol extract of asparagus.

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Abstract

The invention discloses application of an asparagus extract in preparing a medicine for treating inflammation, and particularly relates to application of the asparagus extract in preparing a medicinefor treating vascular smooth muscle cell inflammation. The asparagus extract can also be used to prepare a medicine for treating diseases associated with the inflammation, including hypertension, atherosclerosis, coronary heart disease, myocardial infarction, cerebral apoplexy, and the like. The invention also provides the medicine for treating inflammation, and the medicine is prepared from the asparagus extract and a pharmaceutically acceptable carrier or auxiliary material. Active ingredients are extracted from asparagus, and the above application can be realized and has important medical and economic significance.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to the application of asparagus extracts in the preparation of medicines for treating inflammation and the medicines. Background technique [0002] Inflammation is the body's defense response to stimuli, including injury, tissue damage, and infectious pathogens. It is an adaptive immune response, which includes chronic inflammation and acute inflammation. Oxidative stress and inflammation in the body promote and inhibit each other, and the two have an inseparable internal relationship. The activation of inflammatory signaling intermediates is achieved by regulating the thiol (R-SH) group that modifies ROS / GSH. The generation of excessive reactive oxygen species (ROS) disrupts the redox balance of the body, and through the nuclear transcription factor κB (NF- κB) amplifies the inflammatory response, thereby inducing the transcription of pro-inflammatory cytokines such as TNF-α, IL...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P29/00A61P9/12A61P9/10A61P25/00
CPCA61K36/899A61K2236/333A61K2236/39A61P9/10A61P9/12A61P25/00A61P29/00
Inventor 王晓乔勇进陈冰洁刘晨霞张怡王春芳
Owner SHANGHAI ACAD OF AGRI SCI
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