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Application of lncRNA in preparation of products for predicting prognosis of head and neck squamous cell carcinoma

A squamous cell carcinoma, product technology, applied in DNA/RNA fragment, recombinant DNA technology, microbial assay/inspection, etc., can solve the problem of undiagnosed head and neck cancer, etc.

Inactive Publication Date: 2019-10-15
蔡耿明
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  • Abstract
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Problems solved by technology

But so far, there is no mature technique of using lncRNA to judge the prognosis of head and neck cancer

Method used

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  • Application of lncRNA in preparation of products for predicting prognosis of head and neck squamous cell carcinoma
  • Application of lncRNA in preparation of products for predicting prognosis of head and neck squamous cell carcinoma
  • Application of lncRNA in preparation of products for predicting prognosis of head and neck squamous cell carcinoma

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Embodiment Construction

[0026] The foregoing technical solution of the present invention is based on the discovery of several key characteristic lncRNAs that affect the prognosis of head and neck squamous cell carcinoma, and a disease prognosis scoring model is constructed on this basis.

[0027] Specifically, the applicant analyzed and screened lncRNAs that have an impact on prognosis through bioinformatics methods, and obtained RP11-180M15.7, RP11-197N18.2, AC021188.4, RP11-474D1.3, RP11-347C18.5 A total of 5 lncRNAs are closely related to the prognosis of head and neck cancer, and they are involved in the KEGG (Kyoto Encyclopedia of Genes and Genomes, Kyoto Encyclopedia of Genes and Genomes) pathway in the development of multiple cancers.

[0028] In this paper, the five lncRNAs in the three co-expression modules obtained were enriched and analyzed by the R package cluster Profiler, and the enriched pathways were found to be related to signal transduction, cell cycle, DNA replication, oocyte meiosi...

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Abstract

The invention relates to an application of lncRNA in preparation of products for predicting prognosis of head and neck squamous cell carcinoma, wherein lncRNA is a combination of RP11-180M15.7, RP11-197N18.2, AC021188.4, RP11-474D1.3 and RP11-347C18.5. In the specific embodiment, the product can be a chip or a kit or a detection device, and can also be a reagent for detecting the expression levelof RP11-180M15.7, RP11-197N18.2, AC021188.4, RP11-474D1.3 and RP11-347C18.5 in a sample to be tested. The reagent can be a probe for specially identifying RP11-180M15.7, RP11-197N18.2, AC021188.4, RP11-474D1.3 and RP11-347C18.5, and can also be a primer for specifically amplifying RP11-180M15.7, RP11-197N18.2, AC021188.4, RP11-474D1.3 and RP11-347C18.5. The application or product can reliably predict the prognosis of head and neck squamous cell carcinoma.

Description

technical field [0001] The present invention relates to a product and application for medical treatment, in particular to a product or device for prognosis of squamous cell carcinoma of the head and neck. Background technique [0002] Head and neck squamous cell carcinoma (HNSCC) is a common head and neck malignant tumor clinically, among which pharyngeal squamous cell carcinoma (PSCC), laryngeal squamous cell carcinoma Laryngeal squamous cell carcinoma (LSCC) and oral squamous cell carcinoma (OSCC) are the most common, accounting for about 5% to 10% of systemic malignant tumors, with an average incidence of about 10 to 15 / 100,000. According to research reports, in recent years, the incidence of such highly malignant tumors has been on the rise. Despite the rapid development of medical technology and the continuous improvement of early diagnosis techniques for head and neck squamous cell carcinoma, clinically advanced cases still account for about 50%. In the past 20 years...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/113
CPCC12Q1/6886C12Q2600/178C12Q2600/158
Inventor 蔡耿明
Owner 蔡耿明
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