Immune checkpoint inhibitor treatment related biomarker interpretation system and construction method and device thereof

A biomarker and immune checkpoint technology, applied in bioinformatics, instrumentation, genomics, etc., can solve the problems of no priority in drug recommendation for immune checkpoint inhibitors, inaccurate drug guidance, and incomplete data collection

Active Publication Date: 2019-10-15
深圳裕策生物科技有限公司
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Problems solved by technology

[0004] The purpose of the present invention is to provide a construction method of an immune checkpoint inhibitor treatment-related biomarker interpretation system, a method for guiding and adapting immune checkpoint inhibitor treatment medication, a device, and a storage medium to solve the problem of tumor immune checkpoint inhibitor treatment. In the process of medication guidance, there are scattered data, incomplete data collection, cumbersome query procedures, and no

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  • Immune checkpoint inhibitor treatment related biomarker interpretation system and construction method and device thereof
  • Immune checkpoint inhibitor treatment related biomarker interpretation system and construction method and device thereof
  • Immune checkpoint inhibitor treatment related biomarker interpretation system and construction method and device thereof

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Embodiment

[0135] The detection results of immune-related biomarkers were EGFR L858R mutation, TP53 H179R mutation, MDM2 copy number 8.3, PD-L1 expression 6-10%, MSI-L 6.46%, TMB-M 6.03Muts / Mb, TNB-M2. 01Neos / Mb patients with non-small cell lung cancer are given guidance on the treatment of immune checkpoint inhibitors.

[0136] 1. Interpretation of the drug use of immune checkpoint inhibitors for EGFR L858R mutation

[0137] [1-0201] Adaptation of biomarker information:

[0138] After querying public data resources, it was judged that the EGFR L858R mutation had clinical significance. Match the biomarker EFRL858R mutation with the biomarker name and biomarker status of the immune checkpoint inhibitor-related clinical evidence unit in the immune checkpoint inhibitor medication interpretation system, and screen out those whose biomarker information matches clinical evidence. The screening results are as follows in Table 1:

[0139] Table 1

[0140]

[0141] [1-0202] Tumor type inf...

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Abstract

The invention discloses a guidance system for immune checkpoint inhibitor treatment medication. The system comprises an immune checkpoint inhibitor related biomarker interpretation system and a construction method thereof, a medication guidance adaptation method and device and a storage medium, wherein the construction method of the interpretation system comprises the steps: obtaining public dataresources which comprise biomarker information related to tumor immune checkpoint inhibitor treatment and the like; screening and classifying the public data resources, and determining the key fieldsand attributes of information to be input into the interpretation system; carrying out grade classification on the immune checkpoint inhibitor related clinical evidence information; establishing a structural framework of the interpretation system; and inputting the key field information into a corresponding field position of the interpretation system structure framework according to a unified standardized input rule. According to the method, the problems that in the immune checkpoint inhibitor treatment medication guidance process, the scattered data, incomprehensive data collection, tedious query procedures, and inaccurate medication guidance caused by the fact that immune checkpoint inhibitor medication recommendation has no priority, are solved.

Description

technical field [0001] The present invention relates to the technical field of precision medicine, and in particular to a construction method of an immune checkpoint inhibitor treatment-related biomarker interpretation system, a medication guidance adaptation method for immune checkpoint inhibitor treatment, a device, and a storage medium. Background technique [0002] Tumor is a disease caused by the accumulation of genetic mutations, and there are a large number of different genetic mutations in tumor cells. Different tumors have different gene mutations, and the gene mutations of different individuals of the same tumor also have great differences. Precision medicine is an inevitable trend in the clinical treatment of tumors. Genetic testing is one of the important means of precision medicine, and targeted drug guidance is currently the most widely used direction for tumor genetic testing. However, authoritative data show that only about 37% of patients can find a potenti...

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Application Information

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IPC IPC(8): G16B50/30G16B20/00
CPCG16B20/00G16B50/30
Inventor 杨洁徐丽陈晨邓乙晓张毅红陈龙昀
Owner 深圳裕策生物科技有限公司
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