Functional streptokinase product improving sleep and preparation method of functional streptokinase product

A technology for improving sleep and thrombolytic enzymes, applied in the field of medicine and health care, can solve problems such as prolactin infertility, reduce male libido, etc., and achieve the effects of promoting secretion, restoring secretion ability, and improving atrophy state.

Inactive Publication Date: 2019-11-05
湖北真福医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, in order to improve sleep, the commonly used method to maintain melatonin levels in middle-aged and elderly people is to directly supplement melatonin. However, long-term use of exogenous melatonin has obvious side effects, such as hypothermia, excessive release Prolactin causes infertility and side effects of reducing male libido; or taking various insomnia treatment drugs such as sleeping pills, but due to drug abuse, it can cause a series of side effects to patients, such as drowsiness, dizziness, bitter mouth, nausea and forgetfulness Wait

Method used

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  • Functional streptokinase product improving sleep and preparation method of functional streptokinase product
  • Functional streptokinase product improving sleep and preparation method of functional streptokinase product

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Effect test

Embodiment 1

[0030] Embodiment 1 of the present invention provides a functional thrombolytic enzyme tablet for improving sleep and a preparation method thereof, comprising the following steps:

[0031] Step 1: Grind the dried wild jujube, cassia seed, gastrodia elata, fleece-flower root, chrysanthemum, and licorice into powder respectively, and set aside;

[0032] Step 2, pass the powdery raw materials in step 1 through a 80-100 mesh sieve, and perform secondary crushing on those that cannot pass through until all are sieved, and set aside;

[0033] Step 3, take 12g of tryptone, 2.5g of plant peptone, 4g of sodium chloride, add water to 1000ml, adjust the pH to 7.2 with sodium hydroxide and hydrochloric acid solution, and then put it in a 121°C autoclave for 10 to 12 minutes to sterilize Prepare tryptone medium for later use; put the strain Subtilisin-QK in the above-mentioned tryptone medium, ferment at 25°C for 15 hours, take the fermentation broth and centrifuge at 10,000r / min for 5min ...

Embodiment 2

[0037] Embodiment 2 of the present invention provides a functional thrombolytic enzyme tablet for improving sleep and a preparation method thereof, comprising the following steps:

[0038] Step 1: Grind the dried wild jujube, cassia seed, gastrodia elata, fleece-flower root, chrysanthemum, and licorice into powder respectively, and set aside;

[0039] Step 2, pass the powdery raw materials in step 1 through a 80-100 mesh sieve, and perform secondary crushing on those that cannot pass through until all are sieved, and set aside;

[0040] Step 3, take 15g of tryptone, 4g of plant peptone, 5g of sodium chloride, add water to 1000ml, adjust the pH to 7.3 with sodium hydroxide and hydrochloric acid solution, and then sterilize it in an autoclave at 121°C for 12-15min. Prepare tryptone medium for later use; put the strain Subtilisin-QK in the above-mentioned tryptone medium, ferment at 25°C for 24 hours, take the fermented liquid and centrifuge at 10000r / min for 5min to obtain the s...

Embodiment 3

[0044] Embodiment 3 of the present invention provides a functional thrombolytic enzyme tablet for improving sleep and a preparation method thereof, comprising the following steps:

[0045] Step 1: Grind the dried wild jujube, cassia seed, gastrodia elata, fleece-flower root, chrysanthemum, and licorice into powder respectively, and set aside;

[0046] Step 2, pass the powdery raw materials in step 1 through a 80-100 mesh sieve, and perform secondary crushing on those that cannot pass through until all are sieved, and set aside;

[0047] Step 3: Take 18g of tryptone, 7g of plant peptone, and 6g of sodium chloride, add water to 1000ml, adjust the pH to 7.3 with sodium hydroxide and hydrochloric acid solution, and then sterilize it in an autoclave at 121°C for 15 to 20 minutes. Prepare tryptone medium for later use; put the strain Subtilisin-QK in the above-mentioned tryptone medium, ferment at 30°C for 20 hours, take the fermented liquid and centrifuge at 10000r / min for 5min to ...

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Abstract

The invention discloses a functional streptokinase product improving sleep. The functional streptokinase product improving sleep is prepared from the following components in parts by weight: 1-15 parts of streptokinase powder, 5-10 parts of bacillus subtilis powder, 20-35 parts of wild jujube powder, 15-20 parts of semen cassiae powder, 15-25 parts of rhizoma gastrodiae powder, 15-25 parts of radix polygoni multiflori, 15-25 parts of flos chrysanthemi powder and 3-5 parts of radix glycyrrhizae powder. Wild jujube, semen cassiae, rhizoma gastrodiae, radix polygoni multiflori, flos chrysanthemiand radix glycyrrhizae have a certain action of promotion of melatonin secretion, and thus the sleep quality of a human body is improved. The invention further discloses a preparation method of the functional streptokinase product improving sleep.

Description

technical field [0001] The invention belongs to the technical field of medicine and health care, and in particular relates to a functional thrombolytic enzyme product for improving sleep and a preparation method thereof. Background technique [0002] Located on top of the diencephalon, the pineal gland is rich in blood vessels and its blood flow is second only to the kidneys. The pineal gland can secrete melatonin, which can affect the body's "biological clock" and regulate sleep. Melatonin can improve sleep, shorten the time of waking up and falling asleep before going to bed, improve sleep quality, reduce the number of awakenings during sleep, shorten the time of light sleep stage, and prolong the time of deep sleep stage. However, with age, the pineal gland gradually shrinks until it calcifies, eventually causing the weakening or even disappearing of the rhythm of the body's biological clock. After the age of 35, with the atrophy of the pineal gland, the melatonin secre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61K36/8988A61P25/20C12N9/54A61K35/742C12R1/125
CPCA61K35/742A61K36/287A61K36/482A61K36/484A61K36/704A61K36/725A61K36/8988A61K38/484A61P25/20C12N9/54C12Y304/21007A61K2300/00
Inventor 王业富胡定邦范宇鹏李靖胡坤坤
Owner 湖北真福医药有限公司
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