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A sers substrate capable of naturally eliminating fluorescent background and its preparation method

A fluorescent background and substrate technology, applied in the field of molecular recognition, can solve the problems of restricted secondary processing and affect the accuracy of experimental data analysis, etc., and achieve the effects of improving specific recognition ability, simple operation, and safe synthesis process

Active Publication Date: 2021-09-17
JILIN NORMAL UNIV
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Problems solved by technology

Although these methods can reasonably correct SERS spectra and eliminate the negative impact of PL on SERS, it is subject to secondary processing, which affects the accuracy of the analysis of experimental data

Method used

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  • A sers substrate capable of naturally eliminating fluorescent background and its preparation method
  • A sers substrate capable of naturally eliminating fluorescent background and its preparation method
  • A sers substrate capable of naturally eliminating fluorescent background and its preparation method

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Embodiment Construction

[0024] The required raw materials of the present invention are as follows:

[0025] Zinc nitrate (Zn(NO 3 ) 2 ·6H 2 O, Shenyang Sinopharm Chemical Reagent Co., Ltd.) is analytically pure;

[0026] Neodymium nitrate (Nd(NO 3 ) 3 ·6H 2 O, Shanghai McLean Biochemical Technology Co., Ltd.) is analytically pure;

[0027] Ammonium bicarbonate (NH 4 HCO 3 , Shenyang Sinopharm Group Chemical Reagent Co., Ltd.) was analytically pure;

[0028] 4-mercaptopyridine (4-MPy, Shanghai Weifang Fine Chemical Co., Ltd.) is analytically pure;

[0029] Absolute ethanol (CH 3 CH 2 OH, Shenyang Sinopharm Chemical Reagent Co., Ltd.) was analytically pure.

[0030] The concrete steps of preparation method of the present invention are:

[0031] 1) Weigh raw materials according to the following weight ratio:

[0032]

[0033] 2) Zinc nitrate hexahydrate and neodymium nitrate hexahydrate were dissolved in 50 mL of deionized water respectively, and magnetically stirred for 20 minutes to p...

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Abstract

The invention discloses a SERS substrate capable of naturally eliminating fluorescent background and a preparation method thereof, belonging to the technical field of molecular recognition. The invention adopts a chemical precipitation method, uses zinc nitrate hexahydrate, neodymium nitrate hexahydrate, and ammonium bicarbonate as raw materials. The molar ratio of the species is ammonium bicarbonate: metal cation (Nd 3+ , Zn 2+ ) = 1:1, with bicarbonate as a precursor, the target product of the present invention, the sea urchin-shaped neodymium-doped zinc oxide material, is prepared. This material naturally eliminates the fluorescence background while enhancing the SERS activity, and has good stability and repeatability. It is an ideal SERS substrate and can be applied in the fields of chemistry, materials science and biomedicine.

Description

technical field [0001] The invention belongs to the technical field of molecular recognition, and specifically relates to a method for preparing a SERS substrate capable of naturally eliminating fluorescent backgrounds through a chemical precipitation method. Background technique [0002] Since the discovery of scattering in 1928, the study of Raman spectroscopy has continued to this day. With the development of laser technology, high-energy radiation sources have improved the problem of weak signal strength. Surface-enhanced Raman scattering (Surface-enhanced Raman Scattering, SERS) spectroscopy is a surface analysis spectroscopy technique that can effectively characterize molecular structure, adsorption behavior, vibration mode and detection interface characteristics. It has aroused great interest and has been widely used in food safety, analytical chemistry, environmental monitoring and other fields. However, the outstanding problems in the application of SERS technolog...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/01G01N21/65
CPCG01N21/01G01N21/658
Inventor 高铭杨硕韩东来姚佳成全英楠苏瑞胡明月杨景海
Owner JILIN NORMAL UNIV
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