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Use of DBNL autoantibody detection reagent in preparation of lung cancer screening kit

An autoantibody and kit technology, applied in biological testing, measuring devices, material testing products, etc., can solve the problems of no DBNL protein, no lung cancer existing technology, etc., and achieve good application prospects, low patient harm, and effective The effect of screening

Pending Publication Date: 2019-11-15
WEST CHINA HOSPITAL SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology allows for efficient detection of small tumors that are potentially fatal or affective on healthy individuals during their lifetime. It uses blood samples from people with these tiny lesions instead of testing them themselves at home.

Problems solved by technology

This patents describes how different types of immune responses occur during lung carcinoma development. These include inflammatory reactions caused by bacteria like Helicobactor pylori, gram negative rods, fungi, viruses, parasites, yeast spores, protozoa, pollen grafted onto plants, animal danderings, foodstuffs containing harmful microorganisms, among others. However, these factors may also lead to specific changes within lungs called autoimmunity.

Method used

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  • Use of DBNL autoantibody detection reagent in preparation of lung cancer screening kit
  • Use of DBNL autoantibody detection reagent in preparation of lung cancer screening kit
  • Use of DBNL autoantibody detection reagent in preparation of lung cancer screening kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Relationship Between DBNL Autoantibodies in Plasma and Lung Cancer

[0026] 1. Clinical data

[0027] Select 3 cases of lung cancer patients and 30 cases of healthy controls. The basic information is as follows:

[0028] Basic Information lung cancer patients healthy control number of people 30 30 age 58±10.5 42±8.9 male ratio 20(66.7％) 13(46.7％)

[0029] 2. Detection principle

[0030] HuProt TM The human protein custom chip is immobilized with DBNL protein. After incubation with serum, DBNL autoantibodies (mainly including IgG, IgM antibodies, and some other types of antibodies) in the serum will bind to it, and the unbound antibodies and other proteins will be removed by washing. Then use anti-human IgM fluorescently labeled secondary antibody (cy5-labeled, red) and anti-human IgG fluorescent secondary antibody (cy3-labeled, green) to detect, and read the signal through a fluorescent scanner. The strength of the sig...

Embodiment 2

[0046] Embodiment 2 The composition of detection kit of the present invention and its application method

[0047] 1. Kit composition

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Abstract

The invention relates to the field of in vitro diagnostic reagents, in particular to a use of a DBNL autoantibody detection reagent in the preparation of a lung cancer screening kit. According to theuse provided by the invention, it is discovered for the first time that the autoantibody level of the DBNL protein in the serum of a lung cancer patient is significantly higher than that of a healthypatient. According to the use provided by the invention, the reagent for detecting a DBNL protein autoantibody is used for preparing the lung cancer screening kit, so that the effective screening of the lung cancer can be realized.

Description

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Claims

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Application Information

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Owner WEST CHINA HOSPITAL SICHUAN UNIV
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