System for predicting probability of poor ovarian response of subject under antagonist regimen, and system for guiding selection of gonadotropin starting medication dose

A subject, follicle stimulating hormone technology, applied in the direction of drug reference, etc., can solve the problems of low ovarian response, low embryo implantation rate, pregnancy rate and live birth rate, adverse pregnancy outcome and other problems

Active Publication Date: 2019-12-13
GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
View PDF8 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During COS, the main problem faced by patients is insufficient number of oocytes retrieved, i.e. low ovarian response, which leads to

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • System for predicting probability of poor ovarian response of subject under antagonist regimen, and system for guiding selection of gonadotropin starting medication dose
  • System for predicting probability of poor ovarian response of subject under antagonist regimen, and system for guiding selection of gonadotropin starting medication dose
  • System for predicting probability of poor ovarian response of subject under antagonist regimen, and system for guiding selection of gonadotropin starting medication dose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0153] In the embodiment, the sample size is estimated first, the total sample size should be >553, and all couples are trying to conceive for at least 12 months.

[0154] According to the following inclusion and exclusion criteria, a total of 561 couples were enrolled in the three reproductive medicine centers for this study, that is, 561 couples who met the following inclusion and exclusion criteria were selected for subsequent research.

[0155] The inclusion criteria were: women aged 20-45 years, body mass index (BMI) ≤ 30, six consecutive menstrual cycles of 25-45 days, normal bilateral ovarian morphology assessed by transvaginal ultrasonography, previous IVF / ICSI- ET cycle number ≤ 2.

[0156] The exclusion criteria were: hydrosalpinx, unilateral ovary AFC>20, polycystic ovary syndrome, other untreated metabolic or endocrine diseases, previous surgery for the ovary or uterine cavity, intrauterine abnormalities, pregnancy within 3 months, Smoking, using oral contraceptiv...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Login to view more

Abstract

The present invention relates to a system for predicting the probability of poor ovarian response of a subject under an antagonist regimen, and a system for guiding the selection of a gonadotropin starting medication dose. The system for predicting the probability of poor ovarian response includes: a data acquisition module for acquiring the age, the anti-Mullerian hormone (AMH) level, the follicle stimulating hormone (FSH) level, the antralfollicle count (AFC) data of the subject; and a module for calculating the probability of poor ovarian response, which is used for calculating the information obtained in the data acquisition module to calculate the probability of poor ovarian response of the subject, and giving a starting dose recommendation for exogenous gonadotropin (Gn) based on thepredicted probability of poor ovarian response.

Description

technical field [0001] The present invention relates to a system for predicting ovarian hyporesponsiveness in a subject under a dosing regimen of an antagonist, and a system for guiding the starting dose range of gonadotropins (Gn). Background technique [0002] In the process of controlled ovulation induction (COS), the number of retrieved eggs is considered to be a powerful predictor of successful pregnancy after IVF-ET (in vitro fertilization-embryo transfer). A study of more than 400,000 people in Europe published in the authoritative journal "Human Reproduction" showed that compared with a lower number of eggs retrieved on the day of egg retrieval, the appropriate number of eggs retrieved significantly increased the live birth rate. During COS, the main problem faced by patients is the insufficient number of oocytes retrieved, that is, low ovarian response, which leads to high cycle cancellation rate and adverse pregnancy outcomes, such as low embryo implantation rate, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G16H70/40
CPCG16H70/40
Inventor 李蓉徐慧玉冯国双韩勇乔杰
Owner GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap