System for predicting probability of poor ovarian response of subject under antagonist regimen, and system for guiding selection of gonadotropin starting medication dose

A subject, follicle stimulating hormone technology, applied in the direction of drug reference, etc., can solve the problems of low ovarian response, low embryo implantation rate, pregnancy rate and live birth rate, adverse pregnancy outcome and other problems
CN110570952AActive Publication Date: 2019-12-13GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
Publication Date
2019-12-13

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Abstract

The present invention relates to a system for predicting the probability of poor ovarian response of a subject under an antagonist regimen, and a system for guiding the selection of a gonadotropin starting medication dose. The system for predicting the probability of poor ovarian response includes: a data acquisition module for acquiring the age, the anti-Mullerian hormone (AMH) level, the follicle stimulating hormone (FSH) level, the antralfollicle count (AFC) data of the subject; and a module for calculating the probability of poor ovarian response, which is used for calculating the information obtained in the data acquisition module to calculate the probability of poor ovarian response of the subject, and giving a starting dose recommendation for exogenous gonadotropin (Gn) based on thepredicted probability of poor ovarian response.
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Description

technical field

[0001] The present invention relates to a system for predicting ovarian hyporesponsiveness in a subject under a dosing regimen of an antagonist, and a system for guiding the starting dose range of gonadotropins (Gn). Background technique

[0002] In the process of controlled ovulation induction (COS), the number of retrieved eggs is considered to be a powerful predictor of successful pregnancy after IVF-ET (in vitro fertilization-embryo transfer). A study of more than 400,000 people in Europe published in the authoritative journal "Human Reproduction" showed that compared with a lower number of eggs retrieved on the day of egg retrieval, the appropriate number of eggs retrieved significantly increased the live birth rate. During COS, the main problem faced by patients is the insufficient number of oocytes retrieved, that is, low ovarian response, which leads to high cycle cancellation rate and adverse pregnancy outcomes, such as low embryo implantation rate, ...

Claims

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