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Triptolide and application of composition of triptolide to preparation of medicine for resisting esophageal cancer

A technology of triptolide and esophageal cancer, applied in the field of medicine

Active Publication Date: 2019-12-31
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, there is no report on triptolide and its combination and synergy with erianin for the treatment of esophageal cancer

Method used

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  • Triptolide and application of composition of triptolide to preparation of medicine for resisting esophageal cancer

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Embodiment Construction

[0027] The following describes the substantive content of the present invention in detail in conjunction with the drawings and embodiments, but does not limit the protection scope of the present invention.

[0028] 1. Experimental materials

[0029] Human esophageal cancer Eca-109 cells were purchased from ATCC, stored in liquid nitrogen, recovered and passaged before use;

[0030] Fetal bovine serum is the product of American GIBCO company;

[0031] DMEM medium is a product of Solarbio;

[0032] Triptolide is a product of Shanghai Yuanye Biotechnology Co., Ltd., with a purity of not less than 98%;

[0033] Erianin is from Chengdu Ruifensi Biotechnology Co., Ltd., with a purity of not less than 98%;

[0034] MTT is a product of Sigma Company in the United States;

[0035] DMSO is a product of Sigma, USA.

[0036] 2. Experimental method

[0037] 1. Cell culture

[0038] Human esophageal cancer Eca-109 cells were treated with DMEM medium (complete medium) containing 10% f...

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Abstract

The invention discloses triptolide and application of composition of triptolide to preparation of medicine for resisting esophageal cancer. A research proves that the triptolide has an obvious inhibition effect on proliferation of human esophageal cancer cells, represents the obvious dose dependence and has the prospect that the triptolide is developed and prepared into the medicine for resistingthe esophageal cancer. The triptolide and natural compound erianin having the effect of resisting the esophageal cancer also have the effect of cooperatively inhibiting the proliferation of the humanesophageal cancer cells, and therefore, the triptolide and the erianin can be prepared into a medicine composition for chemotherapy of the human esophageal cancer.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the use of triptolide and its composition for preparing anti-esophageal cancer drugs. Background technique [0002] Esophageal cancer is the sixth leading cause of cancer death in the world, with a mortality rate as high as 90%. In 2012, there were approximately 456,000 new cases of esophageal cancer and 400,000 deaths in the world, of which developing countries accounted for more than 80% of the global cases. There are many pathogenic factors of esophageal cancer. Currently, it is recognized that drinking, smoking, various chronic stimuli that damage the esophagus and environmental factors are the main causes of esophageal squamous cell carcinoma in China. The survey found that eating hot food, excessive drinking, low income, low body mass index, previous esophageal lesions, not eating on time, eating spicy food and family history of cancer are all factors that increase the risk of esopha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/585A61K31/09A61P1/00A61P35/00
CPCA61K31/09A61K31/585A61P1/00A61P35/00A61K2300/00
Inventor 范智蕊邓晓明王辉卫肖艳
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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