Combined medicine for treating cancer and application thereof

A technology for treating diabetic gangrene and a drug is applied in the field of drugs for treating diabetic gangrene and its preparation, which can solve the problems of leaving severe scars and the like, and achieve the effect of high recovery rate

Inactive Publication Date: 2020-01-10
江苏医盟健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned treatments of diabetic gangrene, regardless of western medicine, traditional Chinese medicine or the combination of traditional Chinese and western medicine, all have deficien

Method used

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  • Combined medicine for treating cancer and application thereof
  • Combined medicine for treating cancer and application thereof
  • Combined medicine for treating cancer and application thereof

Examples

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preparation example Construction

[0028] A preparation method of a medicine for treating diabetic gangrene, comprising the steps of:

[0029] 1) Low-temperature wall breaking: set the Amomum seed, Bletilla striata, Atractylodes macrocephala, Panicum yam, Plumeria frangipani, Golden silk grass, Sophora flavescens, Leucaria and lotus leaf raw materials in the formula at -15℃~-20℃, through The wall breaker is used to destroy the cell wall of the raw drug so that the active ingredients in the cell are exposed;

[0030] 2) Extraction and purification: Put Amomum, Bletilla striata, Atractylodes macrocephala, Rhizoma yam, Plumeria frangipani, Golden silk grass, Sophora flavescens, Rhizoma chinensis and lotus leaf after breaking the wall in step 1) into the extraction kettle, and add the broken wall raw materials 8 to 10 times the weight of the drug, extracted with ethanol with a mass concentration of 20% for 1 to 3 hours, filtered to obtain a filtrate;

[0031] 3) Evaporating and concentrating the filtrate into a th...

Embodiment 1

[0035] A medicine for treating diabetic gangrene, comprising the following raw materials in parts by weight:

[0036]

[0037]

[0038] A preparation method of a medicine for treating diabetic gangrene, comprising the steps of:

[0039] 1) Low-temperature wall breaking: set the raw materials of amomum seed, bletilla striata, atractylodes macrocephala, yam, frangipani, golden silk grass, flavescens, fungus and lotus leaf in the formula at -15°C, and use a wall breaking machine to Destroying the cell wall of the raw drug exposes the active ingredient in the cell;

[0040] 2) Extraction and purification: Put Amomum, Bletilla striata, Atractylodes macrocephala, Rhizoma yam, Plumeria frangipani, Golden silk grass, Sophora flavescens, Rhizoma chinensis and lotus leaf after breaking the wall in step 1) into the extraction kettle, and add the broken wall raw materials The mass concentration of 8 times the drug weight is extracted with 20% ethanol for 1 hour, filtered, extracted...

Embodiment 2

[0043] A medicine for treating diabetic gangrene, comprising the following raw materials in parts by weight:

[0044]

[0045] A preparation method of a medicine for treating diabetic gangrene, comprising the steps of:

[0046] 1) Low-temperature wall breaking: set the raw materials of amomum seed, bletilla striata, atractylodes macrocephala, yam, frangipani, golden silk grass, flavescens, leaker reed and lotus leaf in the formula at -18°C, and use a wall breaking machine to Destroying the cell wall of the raw drug exposes the active ingredient in the cell;

[0047] 2) Extraction and purification: Put Amomum, Bletilla striata, Atractylodes macrocephala, Rhizoma yam, Plumeria frangipani, Golden silk grass, Sophora flavescens, Rhizoma chinensis and lotus leaf after breaking the wall in step 1) into the extraction kettle, and add the broken wall raw materials The mass concentration of 9 times the weight of the drug was extracted with 20% ethanol for 2 hours, filtered, and the...

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Abstract

The invention provides a novel compound composition. The novel compound composition comprises a HIF-1a inhibitor and an ROS inducer. When the two medicines are independently used, the response rates to tumors are relatively low; the combined medicine generates a good effect of inhibiting tumor growth according to an effective administration dosage and an administration mode; the survival rate of apatient is obviously improved; especially, the response rate in osteosarcoma and ovarian cancer is obviously improved; the situation that malignant advanced patients have no drug for use is solved, asolid pharmacological basis is provided for subsequent development of novel small molecular compounds for HIF-1a inhibitors and ROS targets, and in addition, available inhibitors and inducers in theprior art are multiple in variety, the implementation means is simple, and the cost is low.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a medicine for treating diabetic gangrene and a preparation method thereof. Background technique [0002] Diabetic gangrene mostly occurs after the age of 50, and it is more common in the age of 60-70. There are more men than women, the ratio of men to women is 3:2. It is more common in obese or adult diabetic patients with a long course of disease, with an average of about 10 years. The lower extremities are more common in parts, and the upper extremities are rare. Unilateral disease is more common in 80%, and bilateral simultaneous occurrence is rare in 20%. Gangrene can occur suddenly, with severe pain. In most patients, gangrene occurs slowly, with severe nerve damage, pain can be mild to severe, local mild injury, and localized small blisters on the skin. Afterwards, the subcutaneous tissue turns dark red or black, festering and necrosis of extremit...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61P3/10A61P17/02
CPCA61K36/24A61K36/28A61K36/284A61K36/489A61K36/62A61K36/8945A61K36/898A61K36/899A61K36/9064A61K2236/333A61K2236/51A61P3/10A61P17/02A61K2300/00
Inventor 熊晓平
Owner 江苏医盟健康科技有限公司
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