Bacteriostatic gel and preparation process thereof

A technology of gel and octylphenol polyether, which is applied in the direction of antifungal agents, antibacterial agents, local antibacterial agents, etc., can solve the problems of users' allergies or stress reactions, prevent allergies and teratogenic phenomena, and inhibit Pathogens, good experience effect

Pending Publication Date: 2020-01-17
禾博药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main purpose of the present invention is to propose a kind of antibacterial gel, aiming to solve the technical problem that the user will have allergy or stress reaction when using the existing antibacterial gel

Method used

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  • Bacteriostatic gel and preparation process thereof
  • Bacteriostatic gel and preparation process thereof
  • Bacteriostatic gel and preparation process thereof

Examples

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preparation example Construction

[0034] The preparation of the antibacterial gel includes the configuration of two groups of components. First, the antibacterial active component is configured, and the solvent is mixed with the active antibacterial component to obtain component A. The pH value of component A needs to be adjusted. Since there are only water, octoxynol and benzalkonium chloride in component A, the pH value is low, and it is necessary to adjust the pH value by adding caustic soda by titration, so as to adjust the pH value of component A to be consistent with the vaginal compatible with the pH value within. The preparation of component B is to mix the other half of the solvent with the active salt solution and thickener, then stir evenly and completely dissolve to prepare component B. After mixing component A and component B, fully Stir to obtain antibacterial gel.

[0035] Specifically, in the step of "adding caustic soda to component A to adjust the pH value", the final pH value is 5.0-5.8, wh...

Embodiment 1

[0039] Prepare 96.55% double distilled water by weight to volume ratio, place half of the double distilled water in the container and add 0.55% active antibacterial ingredients (wherein by mass ratio, octylphenol polyether-11 and octylphenol polyether-11 25: benzalkonium chloride=7:1), stirring and dissolving to obtain component A, the stirring speed is 400r / min;

[0040] Slowly add caustic soda to component A to adjust the pH value to 5.6;

[0041] Put the other half of double distilled water in the container, add 0.9% active salt solution (wherein the volume ratio of sodium chloride solution and potassium chloride solution is 14:1) and 2% hydroxypropyl methyl Cellulose, stirring and dissolving to obtain component B, the stirring speed is 400r / min;

[0042] Component A and component B were stirred and mixed to obtain the antibacterial gel, and the stirring rate was 400 r / min. 1, the bacteriostatic gel that embodiment 1 obtains is carried out the content detection before and...

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Abstract

The invention discloses a bacteriostatic gel and a preparation process thereof. The bacteriostatic gel includes the following raw materials (by weight): 0.11-0.55% of active bacteriostatic components,0.5-1.2% of an active salt solution, 2-4% of a thickener, and the balance a solvent. The active bacteriostatic components are octylphenylpolyethylene glycol and benzalkonium chloride, and the mass ratio of the octylphenylpolyethylene glycol to benzalkonium chloride is (6-10): 1. The octylphenylpolyethylene glycol is at least one of octoxynol-10, octoxynol-11, octoxynol-12, octoxynol-13, octoxynol-16, octoxynol-20, octoxynol-25, octoxynol-30, octoxynol-33, octoxynol-40 and octoxynol-70. The octylphenylpolyethylene glycol and benzalkonium chloride in the bacteriostaticgel composition play a synergistic bactericidal effect, effectively inhibit pathogens, and prevent the reproductive organs from being attacked by a variety of bacteria, viruses, fungi, chlamydia, mycoplasma and trichomoniasis.The octylphenylpolyethylene glycol with a long carbon chain has low absorbability, which protects users from allergic and teratogenic phenomena during non-immediate eluent use, and has a better experience.

Description

technical field [0001] The invention relates to the technical field of gels, in particular to an antibacterial gel and a preparation process thereof. Background technique [0002] Sexually transmitted diseases (STD) refer to various diseases transmitted through sexual contact, similar sexual behavior and indirect sexual contact, including diseases caused by infection of at least 50 pathogenic microorganisms. my country currently requires key prevention and treatment of sexually transmitted diseases. The transmitted diseases are syphilis, gonorrhea, genital chlamydia trachomatis infection, genital warts, genital herpes and AIDS. At present, the prevention methods of sexually transmitted diseases mainly use condoms, oral medicine or external gel to prevent. External gel is widely used because of its reliable effect and convenient use. [0003] However, the cost of the existing antibacterial gel is relatively high, and the main active ingredient Octoxynol-9 in the formula has a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/14A61K31/765A61K9/06A61K47/02A61P31/00A61P31/02A61P31/04A61P31/10
CPCA61K31/14A61K31/765A61K9/0034A61K9/06A61K47/02A61K47/38A61P31/00A61P31/02A61P31/04A61P31/10A61K2300/00
Inventor 王树兴胡杏瑜郭志鹏胡芷晴
Owner 禾博药业有限公司
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