Application of a 12h-indazo[2,1-a]cinnoline-12-one compound

A ketone compound and compound technology, which is applied in the application field of 12H-indazo[2,1-a]cinnoline-12-one compound, can solve the problems of limited curative effect, adverse reactions, urgent drug demand, etc. The effect of good inhibitory activity and great application prospects
CN110742892BActive Publication Date: 2022-05-24ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2022-05-24

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Abstract

The invention discloses the application of a 12H-indazol[2,1-a]cinnoline-12-ketone compound, the 12H-indazol[2,1-a]cinnoline-12-ketone compound The application of the pharmaceutically acceptable salt or hydrate thereof in the preparation of a medicine for treating malignant tumors. The compound has good inhibitory activity especially on human prostate cancer PC-3 cells and human pancreatic cancer PANC-1 cells, and can inhibit their proliferation in a dose-dependent manner, and has great application prospects.
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Description

technical field

[0001] The present invention relates to the application of a class of 12H-indazo[2,1-a]cinnoline-12-one compounds or their pharmaceutically acceptable salts or hydrates in the preparation of antitumor drugs. Background technique

[0002] Cancer is one of the major diseases that seriously affects human health and threatens human life. The World Health Organization (WHO) and national government health authorities have made the fight against cancer a top priority.

[0003] Prostate cancer is one of the common male malignant tumors. There were 161,360 new prostate cancer cases in the United States in 2017, accounting for the first (19%) incidence of male malignant tumors; 26,730 new prostate cancer deaths, accounting for the third male malignant tumor mortality (8%). In 2015, there were 60,300 new cases of prostate cancer in my country, and the incidence of prostate cancer increased by 10% every year. Currently, prostate cancer treatment is based on chemothera...

Claims

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