Application of a traditional Chinese medicine composition in preparation of medicine for treating chronic alcoholic steatohepatitis

A technology for steatohepatitis and a composition, applied in the field of traditional Chinese medicine compositions, can solve the problems such as the unpredictable influence of Xiayuxuetang, achieve good curative effect and expand the scope of application

Active Publication Date: 2021-08-13
SHANGHAI PUTUO DISTRICT CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, the etiology and mechanism of chronic alcoholic steatohepatitis and non-alcoholic steatohepatitis are very different, so it is difficult to predict the effect of Xiayuxue Decoction on chronic alcoholic steatohepatitis

Method used

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  • Application of a traditional Chinese medicine composition in preparation of medicine for treating chronic alcoholic steatohepatitis
  • Application of a traditional Chinese medicine composition in preparation of medicine for treating chronic alcoholic steatohepatitis
  • Application of a traditional Chinese medicine composition in preparation of medicine for treating chronic alcoholic steatohepatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Animal experiment of Chinese medicine composition in the preparation of treatment of chronic alcoholic steatohepatitis

[0025] The research program is as follows:

[0026] (1) The 10-day chronic alcoholic steatohepatitis model was prepared by using the international classic Lieber-Decarli diet plus alcohol (10 days of feeding plus 1 day of Binge).

[0027] (2) The chronic alcoholic steatohepatitis model was prepared by feeding the rats with the international classic Lieber-Decarli diet plus alcohol for 4 weeks.

[0028] The following Yuxue Decoction (drugs: rhubarb, peach kernel, ground beetle) was used as the research object, and the Lieber-Decarli chronic alcoholic steatohepatitis model was used, and Xiayuxue Decoction was intervened at the same time as the model was established. Function, triglycerides and other liver function indicators were used to detect the therapeutic effect of Xiayuxue Decoction on chronic alcoholic steatohepatitis.

[0029] (3) St...

Embodiment 2

[0059] The preparation of embodiment 2 Chinese medicine composition (1)

[0060] Weigh each raw material by weight: 5 parts of rhubarb, 15 parts of peach kernel, and 3 parts of ground soft-shelled beetle, make coarse powder respectively, add 8 times the amount of 15% ethanol respectively, soak for 1 hour, reflux extraction 2 times, add Reflux extraction with 15% ethanol for 30 minutes, filter to obtain the juice; add 6 times the amount of 15% ethanol to the dregs for reflux extraction for 1 hour, filter to obtain the juice, and combine the two extracts. Recover ethanol and use the liquid extract for later use.

Embodiment 3

[0061] The preparation of embodiment 3 Chinese medicine composition (two)

[0062] Take each raw material by weight: 15 parts of rhubarb, 5 parts of peach kernels, and 9 parts of ground beetle, respectively make coarse powder, add 7 times the amount of 25% ethanol respectively, soak for 2 hours, reflux extraction 3 times, add Reflux extraction with 25% ethanol for 30 minutes, filter to obtain the juice; add 8 times the amount of 25% ethanol to the dregs for reflux extraction for 1 hour, filter to obtain the juice, and combine the two extracts. Recover ethanol and use the liquid extract for later use.

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Abstract

The invention relates to an application of a traditional Chinese medicine composition in the preparation of a medicine for treating chronic alcoholic steatohepatitis. The ratio is: 5-15 parts of rhubarb, 5-15 parts of peach kernel, and 3-9 parts of ground beetle. Extract with 30% ethanol for 1-3 times, collect and combine the extracts, recover the ethanol, and obtain the product. The present invention uses Xiayuxue Decoction to treat chronic alcoholic steatohepatitis, and obtains good curative effect, not only expands the application range of Xiayuxue Decoction, but also provides new ideas and ideas for clinical treatment of chronic alcoholic steatohepatitis method.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compositions, in particular to the application of a traditional Chinese medicine composition in medicine for treating chronic alcoholic steatohepatitis. Background technique [0002] Alcoholic liver disease (ALD) refers to the liver damage caused by long-term excessive alcohol, initially manifested as significant hepatic steatosis, and later can progress to steatohepatitis, liver fibrosis and cirrhosis. According to the degree of liver damage in patients, it can be divided into the following types: mild alcoholic liver disease: one or more liver biochemical indicators, imaging and histological examination results are slightly abnormal; alcoholic fatty liver: visible in imaging examination Fatty liver, liver biochemical indicators may be slightly abnormal; alcoholic hepatitis: mainly manifested as elevated serum transaminase and glutamyl transpeptidase levels, usually accompani...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61P1/16A61K35/64
CPCA61K35/64A61K36/708A61K36/736A61K2236/333A61K2236/39A61P1/16A61K2300/00
Inventor 刘成陶乐马文婷吴柳张玮杨广越沈东晓薛冬英张洁
Owner SHANGHAI PUTUO DISTRICT CENT HOSPITAL
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