Health-care food composition for increasing bone mass and inhibiting bone loss, and application of health-care food composition
A technology of health food and composition, applied in the direction of application, baked food, drug combination, etc., can solve the problems of family and social burden, prone to fractures, etc., and achieve the effects of reducing bone loss, increasing bone mass, and increasing bone density
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Embodiment 1
[0033] To study the effect of BB diet on bone formation, we fed 21-day-old male and female Sprague-Dawley rats with AIN-93G diet with or without 10% BB powder for 14 or 40 days, and then evaluated body growth conditions and skeletal changes. The monitoring results showed that there was no significant difference in weight gain among the groups ( figure 1 ), indicating that the BB diet had no effect on body weight.
[0034] To assess differences in bone mass between groups, the left tibia was scanned with pQCT immediately after euthanasia. The study found that after 34 days of BB diet, the amount of trabecular bone in the bone increased significantly, and the bone volume and the number of osteoblasts increased significantly compared with the control group. However, compared with the control group, the number of osteoclasts was significantly inhibited ( figure 2 ).
[0035] Further studies showed that weaning rats on the BB diet for 34 days showed increases in bone mass, inc...
Embodiment 2
[0038] To determine whether the BB diet had a positive effect on the physiological state at the skeletal cellular level, we performed histomorphometric analysis of the bones of male and female rats at 34 and 61 days of age. There was no significant difference in the overall development of the skeleton between the two groups. Long bone sections showed no significant changes in the growth plate. Compared with the control group, at 34 days of age, BB diet-fed female rats had a 30% increase in trabecular bone volume, while BB diet-fed male rats had a 50% increase in trabecular bone volume (p Figure 5 A). At 61 days, both males and females had a 50% increase in trabecular bone volume (p Figure 5 A). The increase in the number of trabeculae was similar to the increase in bone volume. Supplementing the BB diet was associated with increased osteoblast numbers, bone formation rate (BFR) and mineral attachment rate (p Figure 5 A). Rats fed a BB-supplemented diet had a decreased numbe...
Embodiment 3
[0042] Using an animal model of osteoporosis, rats were treated from post-weaning day 20 to postpartum day 34, with a short-term blueberry diet group for 14 days, and then switched to a control diet and ovariectomized. The long-term blueberry diet group adopted a blueberry diet throughout the experiment. The serial tibia sections of each rat were scanned by blind method. Data analysis were taken from slice 3 and slice 4 (mean), parameters were from pQCT analysis. Static and dynamic histomorphological parameters of female rats after OVX were collected. Tissue sections of proximal tibia were stained with VonKossa, one for each group, Von Kossa staining showed double labeling of osteocalcin. The results show that a sustained, early, short-term blueberry diet can prevent bone loss.
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