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Skin repairing polypeptide composition with water-in-oil system

A peptide composition and skin repair technology, applied in skin care preparations, cosmetics, cosmetic preparations and other directions, can solve the problems of difficulty in fully exerting skin repair effects, rising costs, poor stability of polypeptides, etc., and achieve excellent skin repair effects, The effect of improving stability and use safety, and increasing concentration

Pending Publication Date: 2020-02-11
深圳市维琪科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This brings about another problem, that is, peptides are prone to degradation in aqueous solution, and the peptide components are directly added to water-based products, resulting in poor stability of the peptides in the product, so that the peptides with high-efficiency activities cannot be fully exerted Its proper skin repair effect, and the degradation products produced by the degradation of peptides in the product may cause potential harm to the human body
In addition, water-soluble substances are difficult to be absorbed through the skin barrier, and it is difficult to fully exert their skin repairing effect
In order to increase transdermal absorption and achieve the desired effect, it is necessary to increase the amount of feed, which will lead to an increase in cost

Method used

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  • Skin repairing polypeptide composition with water-in-oil system
  • Skin repairing polypeptide composition with water-in-oil system
  • Skin repairing polypeptide composition with water-in-oil system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5 and comparative example 1-5

[0052] The preparation method of embodiment 1-5 and comparative example 1-5 composition:

[0053] 1. Accurately weigh raw materials 5, 6, 7, 8, and 9, add the prescribed amount of raw material 1, and fully dissolve;

[0054] 2. Accurately weigh raw materials 2, 3, and 4, and mix them with the solution obtained in step 1 to get ready. Adopt biological digital microscope to observe the microscopic image of embodiment 3, the results are shown in figure 1 , Many small droplets of uniform size were observed under the microscope at 40*10 times, evenly distributed in the oil phase, forming a water-in-oil system.

Embodiment 1-5、 comparative example 1-5

[0060] 1.3 Test basis

[0061] "Chinese Pharmacopoeia" 2015 Edition Four General Rules 9001 Guiding Principles for Stability Testing of APIs and Preparations

[0062] 1.4 Test conditions and inspection items

[0063] Accelerated test: Constant temperature and humidity chamber at 40°C±2°C, RH75%±5%, respectively, at the first, second, third, and sixth month, detect the peptide content in each sample by HPLC to evaluate its stability.

[0064] Long-term test: Constant temperature and humidity chamber at 25°C±2°C, RH60%±10%, at the 3rd, 6th, 9th, 12th, 18th, 24th, and 36th month respectively, detect the peptide content in each sample by HPLC to evaluate its stability.

[0065] 1.5 Stability test results

[0066] After the samples of Examples 1-5 and Comparative Examples 1-5 were placed under accelerated test conditions for 6 months, the stability data are shown in the following table 1:

[0067] Table 1 accelerates the stability test data of 6 months (content should be 95%-10...

Embodiment 1、 comparative example 1

[0078] 2.3 Test method

[0079] The transdermal properties of the samples were evaluated by vertical Franz diffusion cell method. Fix the isolated skin of SD rat abdomen between the receiving chamber and the supplying chamber of the diffusion cell, take 1g sample on the skin surface of the supplying chamber, the effective diffusion area is 3.14cm 2 , add physiological saline to the receiving tank as the receiving solution, drain the air bubbles so that the side of the dermis is in complete contact with the receiving solution, stir and diffuse at 32°C and 300r / min. Take 0.5mL of receiving solution at 4h, 8h, 12h, 16h, 20h, and 24h respectively, and add an equal amount of constant temperature blank receiving solution in time. The concentration of the polypeptide in the receiving solution was measured by HPLC, and the cumulative transdermal amount of the polypeptide per unit area at different times was calculated according to the following formula:

[0080]

[0081] Among th...

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Abstract

The invention discloses a skin repairing polypeptide composition with a water-in-oil system, and belongs to the technical field of cosmetic polypeptide. The skin repairing polypeptide composition contains polypeptide for promoting generation of collagen proteins; the polypeptide exists an aqueous phase, the concentration of the various polypeptide is 0.0001 percent by mass to 5 percent by mass; and the water-in-oil system is formed by the aqueous phase and an oil phase. The oil phase contains surfactant and oil emollient; and compared with a water-based system, the skin repairing polypeptide composition disclosed by the invention has the advantages that the water-in-oil system is adopted, polypeptide components are dissolved with a less quantity of aqueous phases, so that the concentrationof local polypeptide in the water-in-oil system is higher, percutaneous absorption is carried out more easily, and the growing volume of the skin is higher; even under the condition of same materialfeed capacity, a more excellent skin repairing effect can be achieved, and the composition is high in stability, high in safety, simple in preparation process, low in cost and suitable for industrialproduction in large scale.

Description

technical field [0001] The invention belongs to the technical field of cosmetic polypeptides, and relates to a skin repairing polypeptide composition of water-in-oil system. Background technique [0002] In human skin, 70% is composed of collagen. With the increase of age and the influence of ultraviolet rays, collagen will be lost in large quantities, and the synthesis of collagen and glycosaminoglycans by fibroblasts will also decrease, resulting in hardening and breaking of collagen peptide bonds and elastic nets supporting the skin. The network structure of the dermal layer of the skin is loose, and then it is destroyed, collapsed, and the skin appears loose, wrinkled, dry and other problems. [0003] In the defense and care process of natural skin aging, active peptides play a unique and important physiological role. As an important molecule in the natural process of skin repair, they participate in the process of skin repair in multiple natural states, which can not o...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/06A61K8/81A61K8/37A61K8/92A61Q19/00A61Q19/08
CPCA61K8/64A61K8/064A61K8/8111A61K8/37A61K8/922A61Q19/00A61Q19/08A61K2800/5922
Inventor 丁文锋观富宜彭晏黄春青
Owner 深圳市维琪科技股份有限公司
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