Wrinkle-removing and anti-aging active polypeptide

An active polypeptide and anti-wrinkle technology, which is applied in the field of external skin care drugs, can solve the problems of difficulty in fully exerting anti-wrinkle and anti-aging effects, rising costs, and increasing the amount of ingredients, so as to achieve good anti-wrinkle and anti-aging effects, improve stability and use safety effect

Pending Publication Date: 2019-03-29
宇肽生物(东莞)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the existing anti-wrinkle and anti-aging products, the peptide ingredients are often directly added to the prescription. The problem caused by this is that the stability of the peptide in the product is poor, so that the original anti-wrinkle and anti-aging peptides with high-efficiency activities cannot be fully developed. Play its due effect, and the degradation products produced by the degradation of the peptide in the product may cause potential harm to the human body
In addition, due to the existence of the skin barrier, the exchange of substances inside and outside the body is limited, and the active peptides in the product cannot be absorbed smoothly through the skin barrier, so it is difficult to fully exert its anti-wrinkle and anti-aging effects
In order to increase transdermal absorption and achieve the desired effect, it is necessary to increase the amount of feed, which will lead to an increase in cost

Method used

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  • Wrinkle-removing and anti-aging active polypeptide
  • Wrinkle-removing and anti-aging active polypeptide
  • Wrinkle-removing and anti-aging active polypeptide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] prescription

[0038]

[0039] Preparation:

[0040] 1. Take soybean lecithin, cholesterol, propylene glycol, and 1,2-hexanediol in phase A according to the prescription ratio, stir and dissolve under heating at 40°C, and set aside;

[0041] 2. Take tripeptide-1, Tween 20, disodium hydrogen phosphate, and sodium dihydrogen phosphate in phase B according to the prescription ratio, add warm water (20°C-35°C), stir to dissolve, and set aside;

[0042] 3. Mix phase A and phase B, and pre-emulsify under the condition of 20000rpm through high-speed shearing;

[0043] 4. Homogenize the above mixed solution under high pressure at 22,500 psi and cycle 5 times to obtain the anti-wrinkle and anti-aging active polypeptide encapsulated in nanometers.

[0044] 5. The particle size of the anti-wrinkle and anti-aging active polypeptide nano-inclusions was detected, and the particle size of the inclusions was 38.6nm.

Embodiment 2

[0046] prescription

[0047]

[0048] Preparation:

[0049] 1. Take soybean lecithin, cholesterol, propylene glycol, and 1,2-hexanediol in phase A according to the prescription ratio, stir and dissolve under heating at 40°C, and set aside;

[0050] 2. Take acetyl hexapeptide-8, Tween 20, disodium hydrogen phosphate, and sodium dihydrogen phosphate in phase B according to the prescription ratio, add warm water (20°C-35°C), stir to dissolve, and set aside;

[0051] 3. Mix phase A and phase B, and pre-emulsify under the condition of 20000rpm through high-speed shearing;

[0052] 4. Homogenize the above mixed solution under high pressure at 22,500 psi and cycle 5 times to obtain the anti-wrinkle and anti-aging active polypeptide encapsulated in nanometers.

[0053] 5. The particle size of the anti-wrinkle and anti-aging active polypeptide nano-inclusions was detected, and the particle size of the inclusions was 46.4nm.

Embodiment 3

[0055] prescription

[0056]

[0057] Preparation:

[0058] 1. Take soybean lecithin, cholesterol, propylene glycol, and 1,2-hexanediol in phase A according to the prescription ratio, stir and dissolve under heating at 40°C, and set aside;

[0059] 2. Take acetyl octapeptide-3, Tween 20, disodium hydrogen phosphate, and sodium dihydrogen phosphate in phase B according to the prescription ratio, add warm water (20°C-35°C), stir to dissolve, and set aside;

[0060] 3. Mix phase A and phase B, and pre-emulsify under the condition of 20000rpm through high-speed shearing;

[0061] 4. Homogenize the above mixed solution under high pressure at 22,500 psi and cycle 5 times to obtain the anti-wrinkle and anti-aging active polypeptide encapsulated in nanometers.

[0062] 5. The particle size of the anti-wrinkle and anti-aging active polypeptide nano-inclusions was detected, and the particle size of the inclusions was 53.7nm.

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Abstract

The invention discloses a wrinkle-removing and anti-aging active polypeptide. A nano wrapping body wraps a lipid component for the polypeptide, and further comprises polyol, a surfactant and a pH buffer agent, the mass percentage concentration of the wrinkle-removing and anti-aging active polypeptide is 0.0001%-5%, the mass percentage concentration of the lipid component is 2%-20%, the mass percentage concentration of the polyol is 2%-20%, the mass percentage concentration of the surfactant is 0.1%-10%, and the mass percentage concentration of the pH buffer agent is 0.001%-1%. The wrinkle-removing and anti-aging active polypeptide is good in stability and high in safety; transdermal absorption is facilitated; and compared with an active polypeptide which is not wrapped with the nano wrapping body, the wrinkle-removing and anti-aging active polypeptide which is wrapped with the nano wrapping body has the advantages that the accumulation of the wrinkle-removing and anti-aging active polypeptide on the skin is higher, and the wrinkle-removing and anti-aging effect is more excellent even if the feeding amount is not changed.

Description

technical field [0001] The invention belongs to the field of external skin care medicines, and relates to a wrinkle-removing and anti-aging active polypeptide. Background technique [0002] There are two main types of factors that affect skin aging: endogenous factors and exogenous factors. Genetic factors are the most important endogenous factors affecting skin aging. With age, it is manifested as skin relaxation and wrinkles. Exogenous factors include photoaging, environmental pollution, bad habits, etc. Photoaging is the main exogenous factor affecting skin aging, manifested as dark yellow skin, pigmentation, relaxation, lack of elasticity, roughness, dryness, etc. [0003] The active ingredients used for anti-aging in cosmetics are mainly concentrated in some plant extracts before peptides, and there are also compounds such as vitamin C. Due to the high activity of small molecule peptides, more and more active peptides are used in skin care products. Anti-wrinkle and a...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/11A61Q19/08A61L15/32
CPCA61K8/11A61K8/64A61K2800/413A61L15/32A61Q19/08
Inventor 丁文锋
Owner 宇肽生物(东莞)有限公司
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