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In-vitro lung storage perfusion apparatus

An in vitro and perfusate technology, applied in the preservation, application, animal husbandry and other directions of human or animal body, can solve the problems of isolated lung injury, reduce isolated lung function, failure of lung transplantation, etc., and achieve the elimination of metabolites. , to ensure the effect of the function

Pending Publication Date: 2020-02-14
WUXI PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] In addition, the isolated lungs are in a stable state in the low-temperature environment of the transfer box, which makes the isolated lungs unable to maintain a normal breathing state, and will also cause greater damage to the isolated lungs, reducing the function of the isolated lungs. lead to lung transplant failure

Method used

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Embodiment Construction

[0027] The present invention will be further described below in conjunction with specific drawings and embodiments.

[0028] Such as figure 1 , figure 2 and image 3 Shown: In order to realize the perfusion cleaning of the isolated lung during the transfer process, effectively remove the metabolites produced during the transfer process of the isolated lung, provide the breathing cycle of the isolated lung during the transfer process, and ensure the function, the present invention includes a storage perfusion box 1 that can be used for isolated lung storage and transport; a perfusion circulation mechanism 5 that can be adapted to connect with the isolated lung is set in the storage perfusion box 1 and can be connected with the isolated lung Adaptively connected breathing cycle mechanism 6, the perfusion cycle mechanism 5 and the breathing cycle mechanism 6 are electrically connected to the perfusion breathing controller in the storage perfusion box 1, and the perfusion cycle...

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Abstract

The invention relates to an in-vitro lung storage perfusion apparatus. The apparatus comprises a storage perfusion box body, wherein a perfusion circulation mechanism and a breathing circulation mechanism are arranged in the storage perfusion box body, and the perfusion circulation mechanism and the breathing circulation mechanism are electrically connected with a perfusion breathing controller inthe storage perfusion box body; after the perfusion circulation mechanism is adaptively connected with the pulmonary artery and pulmonary vein of an in-vitro lung, the perfusion breathing controllercontrols the perfusion circulation mechanism to perform continuous perfusate perfusion on the connected in-vitro lung, and metabolites generated by the in-vitro lung can be removed in the perfusate perfusion process; and the perfusion breathing controller controls the breathing circulation mechanism to assist breathing of the in-vitro lung, so that the in-vitro lung can keep a normal breathing state. The apparatus can effectively realize cleaning perfusion of the in-vitro lung in the transferring process, effectively removes metabolites generated in the transferring process of the in-vitro lung, provides breathing circulation of the in-vitro lung in the transferring process, ensures the function of the in-vitro lung in the transferring process, and is safe and reliable.

Description

technical field [0001] The invention relates to a storage and perfusion device, in particular to an isolated lung storage and perfusion device, which belongs to the technical field of isolated lung storage. Background technique [0002] For a lung transplant, the lung needs to be removed first. After the isolated lung is taken out, it is perfused with perfusate and placed in the isolated lung transfer box, and then the isolated lung transfer box and the isolated lung are transported to the destination. Generally, the transfer time of the isolated lung can be up to 6-7 hours or even longer. However, during the transfer process of the isolated lung, since the perfusion operation cannot be performed in the transfer box, the metabolites of the isolated lung will be released in vitro. cannot be excreted from the lungs. After the isolated lung is transplanted, the metabolites in the isolated lung follow the circulation of the body and enter the blood of the recipient, leading to...

Claims

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Application Information

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IPC IPC(8): A01N1/02
CPCA01N1/0247
Inventor 胡春晓黄东晓毛文君秦钟王雁娟高宏
Owner WUXI PEOPLES HOSPITAL
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