The invention provides a polypeptide for inhibiting telomere damage, named TELODIN, which is selected from one of twelve polypeptides for inhibiting telomere dysfunction, including various variants and derivative structures thereof. The polypeptide of the present invention prevents and prevents telomere damage and telomere shortening under stress conditions and without stress, and achieves the result of prolonging telomere, enhancing stem cell expansion, increasing and improving lung respiratory function, increasing the number of skin hair follicles, and prolonging the telomere under stress conditions. The longevity of mice can inhibit the abnormal function of telomeres, delay and anti-aging, prolong life, and prevent lung and skin aging-related diseases and states caused by stress. By inhibiting the damage and shortening of telomeres in cells, Achieve the effects of delaying aging, preventing premature death and preventing related diseases. It can be used in the preparation of medicines for delaying aging and preventing diseases related to telomere dysfunction, including medicines for tissue and organ aging, degeneration, fibrosis, dysfunction and failure related diseases caused by telomere damage.