Quassin compound as well as preparation method and application thereof

A technology of compounds and extracts, applied in the field of bittern compounds and their preparations, can solve the problems of tree vigor decline, leaf shedding, flower and fruit drop, etc., and achieve good poisonous effect

Active Publication Date: 2020-02-21
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the spring citrus tipping period and winter fruit picking period, due to the serious damage of this insect, the leaves often fall off, further causing flower and fruit drop, tree vigor decline, seriously affecting the yield and quality of citrus
[0006] At present, there are no relevant reports on picolidin compounds as insecticides, especially in the control of citrus psyllids and red spiders.

Method used

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  • Quassin compound as well as preparation method and application thereof
  • Quassin compound as well as preparation method and application thereof
  • Quassin compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Preparation and structural characterization of compound 1-23

[0037] 1) Take 46 kg of dry stems of bitter wood, soak them in 95v / v% ethanol for 24 hours, heat and reflux for extraction 4 times (the amount of solvent added during each extraction is 5 times the weight of the raw material, and extract 3 hours each time), combine the extracts, The extract was concentrated under reduced pressure to obtain the extract.

[0038] 2) Suspend the extract in water, extract with ethyl acetate, collect the ethyl acetate part, concentrate, and obtain 572.0 g of extract. The extraction flow chart is as figure 1 As shown, the obtained extract is further separated to obtain the flow chart of each compound as figure 2 shown.

[0039] 3) Apply the extract to silica gel column chromatography, and use dichloromethane-methanol system (V / V, 100:1~3:1) gradient elution, and use TLC thin layer chromatography combined with 210nm ultraviolet lamp irradiation detection during the e...

Embodiment 2

[0089] Embodiment 2: the preparation of compound 1-23

[0090] Repeat Example 1, the difference is that acetone is used as solvent in step 1).

[0091] Compound 1-23 obtained in this example was subjected to structural characterization (infrared, NMR, etc.), and it was determined to be the target compound 1-23 of the present invention.

Embodiment 3

[0092] Embodiment 3: the preparation of compound 1-23

[0093] Repeat Example 1, except that 70v / v% methanol is used as the solvent in step 1).

[0094] Compound 1-23 obtained in this example was subjected to structural characterization (infrared, NMR, etc.), and it was determined to be the target compound 1-23 of the present invention.

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PUM

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Abstract

The invention discloses quassin compounds as well as a preparation method and application thereof. The quassin compounds are a series of compounds which are separated from stems and / or branches and leaves of picrasma quassidioides (D.Don) Benn) which is a picrasma quassidioides plant. Tests show that the compound has a good poisoning effect on diaphorina citri and citrus red mites, and can be usedfor preparing insecticides for preventing and controlling corresponding pests.

Description

technical field [0001] The invention relates to extracting and separating active ingredients from plants, in particular to extracting and separating bitternin compounds from bitter wood and its preparation method and application. Background technique [0002] Bitterlignin compounds only exist in Bitterwoodaceae plants. Because of their structural diversity, scientific researchers have never stopped studying this kind of compounds in recent decades. These compounds are considered to be derived from tetracyclic triterpenoids in biogenesis, so picolidinoids are still classified as triterpenoids. Up to now, more than 200 pectinoids have been isolated and identified from the plants of the family Fraulaceae, and some pectinoids have shown significant anti-tumor, anti-malarial and anti-inflammatory biological activities. [0003] Citrus psyllid [Diaphorina citri (Kuwayama)], also known as Oriental psyllid, Asian psyllid, belongs to the family Psyllidae of Homoptera, distributed in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/06C07D311/78C07D407/06A01N43/90A01N43/16A01P7/02
CPCC07D493/06C07D311/78C07D407/06A01N43/90A01N43/16
Inventor 廖海兵梁东阳廷蜜贺翠
Owner GUANGXI NORMAL UNIV
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