Lung cancer tumor marker detection device and method based on micro-fluidic chip and mobile phone

Abstract

The invention discloses a lung cancer tumor marker detection device and method based on a micro-fluidic chip and a mobile phone. A micro lens group and a collecting lens are fixedly connected to the interior of a first layer structure of a microscopic amplification device. The micro lens group is arranged right below an intelligent mobile phone camera, the collecting lens is arranged right below aflash lamp of an intelligent mobile phone, the interior of a second layer structure is fixedly connected with a total reflection plane mirror positioned below the micro-fluidic chip, a liquid inlet and an observation area are formed in an upper surface of the micro-fluidic chip, filter paper, a reaction tank, a capillary pipeline and a waste liquid tank are arranged inside, a layer of filter paper for stopping blood cells is connected between the reaction tank and the liquid inlet, labeled antibodies of lung cancer markers with different colors of fluorescence are attached to a tank bottom and a tank wall in the reaction tank, a detection strip is printed in the middle of the capillary pipeline, and an antibody probe capable of specifically reacting with the lung cancer markers is printedat a bottom of the detection strip. According to the invention, several common lung cancer serum tumor markers can be detected, and detection reaction information can be accurately acquired.

Description

technical field [0001] The invention relates to the field of medical detection, and is aimed at the detection of lung cancer tumor markers, and specifically uses a smart phone and a microfluidic chip for early detection of lung cancer tumor markers, which is helpful for early screening of lung cancer. [0002] technical background [0003] Lung cancer is a cancer killer with high morbidity and mortality. The best way to treat lung cancer is early detection and early treatment. Therefore, the earlier the detection, the more beneficial it is for the treatment of lung cancer. An important way to detect cancer early is tumor screening. Therefore, it is of great significance to popularize tumor screening and improve the diagnosis rate. [0004] Traditional tumor screening can generally only be done in formal medical institutions with the help of large-scale professional equipment and under the operation of professional technicians, such as serum tumor screening, CT, X-ray examinat...

AI Technical Summary

Problems solved by technology

However, since the device simultaneously detects tumor markers of multiple cancers, the accuracy of the detection cannot be guaranteed

Secondly, in this detection method, the smartphone directly takes pictures of the detection ribbon, and the small cell cancer and tumor markers with low content in the blood are difficult to be photographed by the smartphone, which affects the detection results

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