A multimodal molecular imaging approach for radiation-induced brain injury biomarkers

Abstract

The invention discloses a multi-modal molecular imaging method for radioactive brain injury biomarkers, which specifically includes sequentially image acquisition, image analysis, brain segmentation, white matter fiber tract tracking, network construction and classification of samples. The invention discovers brain function Network connectivity patterns can be used as a starting point for monitoring. According to the idea that structure determines function, the most reliable way to assess brain function is to understand the anatomy of the brain and its underlying brain circuits. Therefore, studying the anatomical network between white matter regions in the brain can supplement the understanding of the pathophysiological mechanism of radiation brain injury, and is of great significance for exploring the neurological basis of cognitive dysfunction after radical radiotherapy.

Description

technical field

[0001] The invention relates to the field of medical detection, in particular to a multimodal molecular imaging method for radiation brain injury biomarkers. Background technique

[0002] Nasopharyngeal carcinoma is a common cancer with high incidence among head and neck malignancies in southern China, and radical radiotherapy is the preferred treatment. However, radical radiotherapy may lead to radiation brain injury, the most serious complication, which can be roughly divided into three stages according to the time of occurrence: acute response phase, early delayed radiation phase, and late delayed radiation phase.

[0003] Damage later in the delayed radiation phase is usually irreversible. Cognitive impairment induced by radical radiotherapy significantly reduces the quality of life of patients with nasopharyngeal carcinoma. Radiation brain injury is most prominent in cognition, memory, and emotion. How to detect radiation-induced brain injury early be...

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