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Nano-selenium hydrosol and preparation method and application thereof

A technology of nano-selenium and hydrosol, which can be used in applications, pharmaceutical formulations, active ingredients of sulfur/selenium/tellurium, etc., can solve the problems of nano-selenium and bone health that are rarely reported, achieve good particle size regulation and stabilization, and avoid Aggregation of precipitates and the effect of increasing intake

Active Publication Date: 2020-03-13
THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there are still few reports on the relationship between nano-selenium and bone health.
[0005] The existing methods for preparing nano-elemental selenium usually adopt the reduction method, using selenium oxysalts or oxides to obtain elemental selenium through various reducing agents, and at the same time using modifiers or regulators to modify and regulate the morphology to obtain ideal particle sizes and morphology of the product, but the resulting product is not functionalized nano-selenium

Method used

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  • Nano-selenium hydrosol and preparation method and application thereof
  • Nano-selenium hydrosol and preparation method and application thereof
  • Nano-selenium hydrosol and preparation method and application thereof

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preparation example Construction

[0045] In one embodiment of the present invention, the present invention provides a kind of preparation method of nano selenium hydrosol, it comprises the following steps:

[0046] (i) Add selenium dioxide solution or selenite solution to the polysaccharide protein solution of Cordyceps mycelium Cs4, and mix uniformly to obtain mixed solution A; Silk Cs4 obtained;

[0047] (ii) Add vitamin C solution to mixed solution A, mix well, and obtain mixed solution B;

[0048] (iii) After the reaction of the mixed solution B is complete, the nano-selenium hydrosol is obtained through dialysis.

[0049] In the above step (i), the polysaccharide protein of Cordyceps mycelium Cs4 can be prepared by the following method: add water to the Cordyceps mycelium Cs4 according to the ratio of the weight ratio of the Cordyceps mycelium Cs4 to water is 1:20, Heat to 95-100°C, extract for 2 hours and take the filtrate; repeat the extraction of the filter residue once according to the previous step...

Embodiment 1～5

[0064] Its preparation method of nano selenium hydrosol is:

[0065] (1) Under normal temperature and pressure, add sodium selenite solution to the Cs4 polysaccharide protein solution of the Cordyceps mycelium, mix well to obtain a mixed solution A; the Cs4 polysaccharide protein solution of the Cordyceps mycelium is extracted by hot water Mycelium Cs4 is obtained; the specific preparation method of the polysaccharide protein solution of Cordyceps mycelium Cs4 is: according to the weight ratio of Cordyceps mycelium Cs4 and water is 1:20, add water to the Cordyceps mycelium Cs4, heat to 95-100°C, take the filtrate after 2 hours of extraction; repeat the extraction of the filter residue once according to the previous steps, and the repeated extraction time is 2 hours, combine the filtrate obtained from the two extractions, dialyze for 24 hours, the molecular weight cut-off is 8,000, and obtain the Cordyceps sinensis Mycelia Cs4 polysaccharide protein.

[0066] (2) Add the reduc...

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Abstract

The invention relates to rapid preparation of novel nano-selenium, specifically to functional nano-selenium hydrosol and a preparation method and application thereof. The preparation method of the novel nano-selenium hydrosol comprises the following steps: (i) adding a selenium dioxide solution or a selenite solution into a Cordyceps mycelium Cs4 polysaccharide protein solution, and uniformly mixing to obtain a mixed solution A; wherein the Cordyceps mycelium Cs4 polysaccharide protein solution is obtained by water extraction of Cordyceps mycelium Cs4; (ii) adding a vitamin C solution to the mixed solution A and mixing evenly to obtain a mixed solution B; and (iii) performing a reaction completely on the mixed solution B, and carrying out dialysis to obtain the nano-selenium hydrosol. TheCordyceps mycelium Cs4 polysaccharide protein with wide biological activity is used as a nano-selenium functional factor to obtain the novel nano-selenium hydrosol with bone growth promotion functionand good stability. The novel nano-selenium hydrosol can be used for promoting bone development in children and adolescents and preventing and treating osteoporosis, bone loss, fracture and other disease states in middle age.

Description

technical field [0001] The invention relates to the rapid preparation of novel nano-selenium, in particular to a functionalized nano-selenium hydrosol and its preparation method and application. Background technique [0002] Osteoporosis is a metabolic bone disease characterized by decreased bone density and degeneration of bone microarchitecture, leading to increased bone fragility and increased fracture risk. With the aging of the world, osteoporosis has become a serious public health problem, affecting more than 200 million people worldwide, and causing huge economic and medical burdens on society. In 2010, there were more than 23 million cases of fractures caused by osteoporosis in China, and the medical expenses involved were as high as US$10 billion, which is expected to increase significantly to US$25.4 billion in 2050. Therefore, we urgently need to develop a new method to prevent and treat osteoporosis. [0003] Osteoporosis is due to the imbalance of osteogenesis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/04A61K9/06A61K47/64A61P19/08A61P19/10A23L33/16A23L33/185
CPCA61K33/04A61K9/06A61K47/64A61P19/10A61P19/08A23L33/16A23L33/185A23V2002/00A23V2200/306A23V2250/548A23V2250/208A23V2250/1626
Inventor 黄家兴董晓莉陆家谦张兆滔
Owner THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST
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