Eye drop for treating myopia and preparation method thereof

An eye drop, myopia technology, applied in non-active ingredients medical preparations, pharmaceutical formulations, sensory diseases, etc., can solve problems such as instability, achieve improved stability, suitable pH and osmotic pressure, and realize industrialized production Effect

Inactive Publication Date: 2020-03-27
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the unstable problem of existing low-concentration atropine eye drops,

Method used

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  • Eye drop for treating myopia and preparation method thereof
  • Eye drop for treating myopia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The present embodiment provides a kind of eye drops for the treatment of myopia, and the prescription dosage is as shown in the table below:

[0030]

[0031]

[0032] The preparation method of the above-mentioned eye drops for the treatment of myopia is as follows:

[0033] Get the hydroxypropyl methylcellulose, EDTA and sodium chloride of prescription quantity, add in 80g 80 ℃ water for injection, stir and dissolve, place to room temperature, obtain mixed solution; Add boric acid, borax of prescription quantity, adjust described When the pH of the mixed solution reaches 5.0, add the prescribed amount of atropine sulfate, mix evenly, add water for injection to 100 g, filter, sterilize, and aseptically subpackage to obtain the eye drops for treating myopia.

Embodiment 2

[0035] The present embodiment provides a kind of eye drops for the treatment of myopia, and the prescription dosage is as shown in the table below:

[0036] components Dosage Atropine sulfate 0.001g boric acid 1.8g Sodium hyaluronate 0.5g EDTA 0.01g water for injection to 100g

[0037] The preparation method of the above-mentioned eye drops for the treatment of myopia is as follows:

[0038] Take the prescribed amount of sodium hyaluronate, hydroxypropyl methylcellulose and EDTA, add 80g of 75°C water for injection, stir to dissolve, and leave it to room temperature to obtain a mixed solution; use boric acid to adjust the pH of the mixed solution to 5.0, Add the prescribed amount of atropine sulfate, mix well, add water for injection to 100g, filter, sterilize, and aseptically pack to obtain the eye drops for treating myopia.

Embodiment 3

[0040] The present embodiment provides a kind of eye drops for the treatment of myopia, and the prescription dosage is as shown in the table below:

[0041] components Dosage Atropine sulfate 0.1g trisodium citrate 1.76g citric acid 0.84g Hydroxypropylmethylcellulose 2g Sodium chloride 0.24g EDTA 0.05g water for injection to 100g

[0042] The preparation method of the above-mentioned eye drops for the treatment of myopia is as follows:

[0043] Take the prescribed amount of hydroxypropyl methylcellulose, sodium chloride and EDTA, add 80g of 85°C water for injection, stir to dissolve, and leave it to room temperature to obtain a mixed solution; add the prescribed amount of citric acid and trisodium citrate to adjust the pH to 5.0, add the atropine sulfate of the prescribed amount, mix uniformly, add water for injection to 100g, filter, sterilize, and aseptically pack to obtain the eye drops for the treatment of myopia.

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Abstract

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an eye drop for treating myopia and a preparation method thereof. The eye drop comprises atropine sulfate, a thickening agent, a pH regulator, an osmotic pressure regulator and a metal ion chelating agent, wherein the solvent is water, the content of atropine sulfate is 0.001-0.1 wt%. The eye drop for treating myopia is a low-concentration atropine sulfate eye drop, and the metal ion chelating agent is selectively added. Moreover, the eye drop is supplemented with auxiliary materials for improving the stability of atropine sulfate, such as the pH regulator, the osmotic pressure regulator and the thickening agent, so that the stability of the low-concentration atropine sulfate solution isobviously improved, the safety is good, the occurrence of myopia of teenagers can be effectively prevented and delayed, the irritation to eye tissue cells is small, and the eye drop is particularly suitable for teenagers with myopia below 400 degrees.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an eye drop for treating myopia and a preparation method thereof. Background technique [0002] At present, myopia has become the most common disease among teenagers. Especially this year, teenagers and children have heavy learning tasks, and there are more and more electronic products. People are increasingly relying on computers, TVs and other video display terminals for various activities, continuous long hours of work or study, and improper The excessive use of eyes has led to a high incidence and younger age of myopia among teenagers in our country, which seriously affects children's life and study. The myopia rate among young people in my country is as high as 50-60%, and the number of myopia increases by about 6% every year. The existing means of treating myopia mainly include optometry and refractive surgery. Although they can correct the visual abno...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/46A61K47/18A61P27/10
CPCA61K9/0048A61K31/46A61K47/183A61P27/10
Inventor 高子彬李晨晨付玉飞黄德胜孟思李玲玲霍月香臧香环李硕张惠敏孙艳平孙勇军
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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