Chinese herbal compound mixture for treating liver cirrhosis and preparation method thereof

Abstract

A Chinese herbal compound mixture for treating liver cirrhosis and a preparation method thereof are disclosed. The Chinese herbal compound mixture includes the following substances: 80-120 parts of turtle shell, 80-120 parts of Chinese yam, 80-120 parts of Astragalus membranaceus, 80-120 parts of rhizoma polygoni cuspidate, 80-120 parts of herba cistanche, 80-120 parts of barbed skullcap herb, 40-80 parts of Belamcanda chinensis, 40-80 parts of Codonopsis pilosula, 40-80 parts of rhizoma polygonati, 40-80 parts of peach kernel, 40-80 parts of Draba nemorosa L., 10-50 parts of donkey-hide gelatin, 10-50 parts of armadillidiam vulgare, 10-50 parts of pink herb, 10-50 parts of Scutellaria baicalensis, 10-50 parts of radix bupleuri, 10-50 parts of rhizoma zingiberis, 10-50 parts of Mangnolia officinalis, 10-50 parts of campsis grandiflora, 10-50 parts of leech, 10-50 parts of nidus vespae, 10-50 parts of dung beetle, 5-35 parts of rheum officinale, 5-35 parts of cortex moutan, 5-35 parts of cassia twig, 5-35 parts of ground beeltle, and 5-35 parts of rhizome paridis. The invention also provides a preparation method of the Chinese herbal compound mixture. The invention has the advantages as follows: the Chinese herbal compound mixture is free of toxic and side effects, definite in curative effect and good in prognosis, can inhibit (HBsAg) replication, can delay liver fibrosis, can reduce ascites and can recover hypersplenism to a normal range; the preparation method is simple and easy to implement, is low-cost and is capable of achieving large-scale production.

Description

technical field [0001] The invention relates to the field of pharmaceutical compound preparations, in particular to a traditional Chinese medicine compound mixture for treating portal vein widening, gastric variceal bleeding and hypersplenism caused by liver cirrhosis and a preparation method thereof. Background technique [0002] Liver cirrhosis is a common clinical chronic progressive liver disease, which is diffuse liver damage caused by long-term or repeated effects of one or more causes. In my country, most of them are post-hepatitis cirrhosis, and a small part are alcoholic cirrhosis and schistosome cirrhosis. Histopathologically, extensive liver cell necrosis, nodular regeneration of residual liver cells, connective tissue hyperplasia, and fibrous septum formation lead to structural destruction of hepatic lobules and formation of pseudolobules. The liver gradually deforms and hardens and develops into cirrhosis. In the early stage, there are no obvious symptoms due t...

AI Technical Summary

Problems solved by technology

However, most patients with liver cirrhosis and portal hypertension are not suitable for surgery or cannot tolerate surgery; sclerotherapy and varicose vein ligation have more adverse reactions; drug prevention is mostly carried out from the perspective of hemodynamics, including non-selective β receptor blockers, nitrate vasodilators and calcium channel blockers, etc. These drugs can slow down the occurrence of esophageal variceal bleeding to a certain extent, but have no obvious effect on liver cirrhosis itself that causes portal hypertension, and cannot Prevent the progression of liver fibrosis and the increase of intrahepatic and portosystemic vascular resistance caused by liver cirrhosis, while the commonly used lamivudine, afovir, and entecavir can only inhibit the replication of hepatitis B surface antigen (HBsAg) and supplement human blood Protein can only reduce the amount of ascites, and both of them still have to undergo splenectomy when they have hypersplenism, which brings serious economic losses and mental pain to patients

In addition, some Biejiajian pills made by ordinary techniques are used to treat liver cirrhosis, which have poor absorption, little curative effect, and poor prognosis

[0005] Therefore, the medical treatment of liver cirrhosis has the characteristics of insignificant therapeutic effect and large side effects, and there is still a lack of safe and effective therapeutic drugs in clinical practice.

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