Expiration detection method and device for helicobacter pylori infection and related inflammation

A technology of Helicobacter pylori and inflammation, applied in the field of breath detection of Helicobacter pylori infection and inflammation and related diseases, can solve the problems of unpublished patents, unresearched or even mentioned, etc.

Active Publication Date: 2020-04-10
SUNVOU MEDICAL ELECTRONICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problems in these detection technologies, the detection of breath NO for Hp infection and infla...

Method used

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  • Expiration detection method and device for helicobacter pylori infection and related inflammation

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Experimental program
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Effect test

specific Embodiment 1

[0019] In this embodiment, an exhaled NO detection device modified based on Sunvo Medical’s Nacoulomb breath analyzer is used: figure 1 Shown is a label-free breath detection device for Helicobacter pylori infection and related diseases, which is composed of a breath sampling module and a breath analysis module. The breath sampling module consists of an expiratory tube, a pressure sensor, and a CO 2 Sensor, three-way solenoid valve and air chamber, exhalation tube, CO 2 The sensor, three-way solenoid valve one and the air chamber are connected in series, the other interface of the three-way solenoid valve one is connected to the atmosphere, and the pressure sensor is connected to the expiratory tube and CO 2 On the pipeline between the sensors; the exhalation analysis module is composed of a gas filter device, three-way solenoid valve two, analysis pump, humidity regulator and NO sensor, three-way solenoid valve two is connected to the three-way solenoid valve one and the air chamb...

specific Embodiment 2

[0032] According to the detection method and device of specific embodiment one, 42 volunteers were tested for exhaled NO before and after taking the substrate. 42 volunteers were divided into three groups according to the diagnosis of Helicobacter pylori (Hp) infection by C14 urea breath test and the presence or absence of symptoms of chronic gastritis. The difference between the exhaled NO measurement before and after taking the substrate is as follows

[0033] Grouping Number of people Exhale NO before taking the substrate Exhaled NO increases after taking the substrate Hp negative asymptomatic16 7.4± 3.1 ppb 2.6± 1.4 ppb Hp positive asymptomatic14 8.8 ± 4.2 ppb 5.4 ± 2.9 ppb Hp positive has symptoms12 10.6 ± 5.4 ppb 9.8 ± 4.5 ppb

[0034] The data analysis of the above examples showed that the three groups of subjects with Hp negative asymptomatic, Hp positive asymptomatic (Hp infection but no inflammation), Hp positive with symptoms (Hp infection + inflammation), exhale...

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Abstract

The invention provides an expiration detection method and device for helicobacter pylori infection and related inflammation. The method and device are characterized in that: general beverages and foodare forbidden for 3 hours before testing, and barbecue food is forbidden for 8-12 hours; the expiration NO concentrations before and after administration of a substrate capable of promoting NO generation and stabilization are detected; and helicobacter pylori infection and related inflammation are detected according to the difference change of expiration NO before and after administration of thesubstrate. The substrate for realizing the method consists of urea, acid and salt in a certain proportion. The expiration NO detection device is composed of an expiration sampling module and an expiration analysis module and comprises an expiration flow sensor, a pressure sensor, a temperature and humidity sensor, a CO2 sensor and an NO sensor.

Description

Technical field [0001] The invention relates to the field of breath detection of Helicobacter pylori infection and inflammation and related diseases. Background technique [0002] At present, the routine detection method for Helicobacter pylori (Hp) infection is the C13 or C14-labeled urea breath test. Its disadvantages include, but are not limited to: (1) C13-labeled urea is difficult to obtain and expensive, while C14 has Radiation problems; (2) It can only detect Hp, but cannot diagnose the degree of Hp infection and inflammation caused by Hp infection. [0003] The detection of endogenous NO in the stomach may help solve the above problems. Lipopolysaccharides, urease and ammonia related to Hp infection and inflammatory cytokines secreted by activated cells will all up-regulate inducible NO synthase (iNOS) and synthesize more NO. Therefore, the NO concentration level increases for Hp infection, and the inflammation caused by Hp infection will further increase. Detection of e...

Claims

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Application Information

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IPC IPC(8): G01N33/48G01N33/00G01N1/22
CPCG01N1/2247G01N33/0037G01N33/48
Inventor 韩益苹韩杰
Owner SUNVOU MEDICAL ELECTRONICS
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