Application of geraniin in preparation of medicine for treating osteoporosis combined fracture

A technology of geranium and osteoporosis, which is applied in the field of biomedicine to achieve the effect of strong therapeutic effect, reducing risk and promoting healing

Pending Publication Date: 2020-05-01
KUNMING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of geraniin in the treatment of osteoporosis with fractures has not been reported

Method used

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  • Application of geraniin in preparation of medicine for treating osteoporosis combined fracture
  • Application of geraniin in preparation of medicine for treating osteoporosis combined fracture
  • Application of geraniin in preparation of medicine for treating osteoporosis combined fracture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Geraniin is obtained by the following methods:

[0038] 1) The ratio of solid to liquid is 1:14. Add the extract containing 0.8% lactic acid, 22% ammonium sulfate and 19% ethanol to the powder of Phyllanthus phylloxera, and extract it under 160W ultrasonic wave for 45min. Centrifuge at 10,000r / min for 8min, put the supernatant in a separatory funnel for stratification, and filter through a 0.45μm microporous membrane to obtain an extract. The extraction rate of phenolic substances is 8.83%;

[0039] 2) Prepare a solvent system with petroleum ether, ethyl acetate, methanol, ammonium citrate, and water according to the volume ratio of 0.5:10:0.2:0.05:20, place it in a separatory funnel, shake it up, let it stand for stratification, and wait for equilibrium After 2h, separate the upper phase and the lower phase, take the upper phase as the stationary phase, and the lower phase as the mobile phase;

[0040] 3) Fill the column of the high-speed countercurrent chromatograph ...

Embodiment 2

[0042] Geraniin is obtained by the following methods:

[0043] 1) The ratio of solid to liquid is 1:14. Add the extract containing 0.8% lactic acid, 22% ammonium sulfate and 19% ethanol to the powder of Phyllanthus phylloxera, and extract it under 160W ultrasonic wave for 45min. Centrifuge at 10,000r / min for 8min, put the supernatant in a separatory funnel for stratification, and filter through a 0.45μm microporous membrane to obtain an extract. The extraction rate of phenolic substances can reach at least 5.44%;

[0044] 2) Prepare a solvent system with petroleum ether, ethyl acetate, methanol, and water at a volume ratio of 0.5:10:0.2:20, place it in a separatory funnel, shake it up and let it stand for stratification. After equilibrating for 2 hours, put the upper phase Separate from the lower phase, take the upper phase as the stationary phase, and the lower phase as the mobile phase;

[0045] 3) Fill the column of the high-speed countercurrent chromatograph with the stat...

Embodiment 3

[0048] Geraniin is obtained by the following methods:

[0049] 1) The ratio of solid to liquid is 1:14. Add the extract containing 0.8% lactic acid, 22% ammonium sulfate and 19% ethanol to the powder of Phyllanthus phylloxera, and extract it under 160W ultrasonic wave for 45min. Centrifuge at 10,000r / min for 8min, put the supernatant in a separatory funnel for stratification, and filter through a 0.45μm microporous membrane to obtain an extract;

[0050] 2) Prepare a solvent system with petroleum ether, ethyl acetate, methanol, and water at a volume ratio of 0.5:10:0.2:20, place it in a separatory funnel, shake it up and let it stand for stratification. After equilibrating for 2 hours, put the upper phase Separate from the lower phase, take the upper phase as the stationary phase, and the lower phase as the mobile phase;

[0051] 3) Fill the column of the high-speed countercurrent chromatograph with the stationary phase at a flow rate of 12mL / min, then run the main engine of ...

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PUM

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Abstract

The invention provides an application of geraniin in preparation of a medicine for treating osteoporosis combined fracture, and belongs to the technical field of biological medicines, and the geraniincan promote healing of combined fracture, improve bone mineral density of osteoporosis, improve fracture strength, bone ash weight and bone calcium content, and reduce the risk of re-occurrence of fracture. The invention further provides a medicine for treating osteoporosis combined fracture. The medicine comprises geraniin; the medicine is applied according to the amount of 1-200 mg / kg geraniinper day, is applied once per day or is applied in 2-4 times per day, and is applied in a manner of being taken for 9-12 weeks or more.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the use of geraniin in the preparation of medicines for treating osteoporosis combined with fractures. Background technique [0002] Osteoporosis (ostcoporosis, OP) is a systemic degenerative disease of bone tissue structure, and the elderly are prone to this disease. OP is a high-risk factor for fractures. The incidence of OP combined with fractures in the population over 60 years old is about 12.2%. The pace of population aging in my country is accelerating. The number of fractures caused by OP is increasing year by year, which seriously threatens the life and health of the elderly and brings heavy burdens to families and society. burden. Because OP is a progressive disease, if it is not effectively controlled and treated, the risk of refracture is still high even after the fracture has healed. At present, the prevention and treatment of osteoporosis mainly inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P19/10A61P19/08
CPCA61K31/7048A61P19/10A61P19/08
Inventor 陈鹏沈志强杨仁华李璠何波张莉
Owner KUNMING MEDICAL UNIVERSITY
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