Composition for suppressing obesity

A composition and obesity technology, applied in the direction of drug combination, drug delivery, plant raw materials, etc., can solve the problems of side effects and drug resistance, concurrent malabsorption, obesity and other problems, and achieve good stability and unaffected immunity , suitable for long-term storage effect

Active Publication Date: 2021-01-15
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surgical treatments such as gastric bypass surgery and gastroplasty have potential risks of concurrent malabsorption, anemia, and pipeline stenosis. The most important problem is that the root cause of the obesity problem cannot be solved, so the problem of obesity rebound cannot be solved
[0005] In short, the current treatment methods for obesity have problems or defects such as side effects and drug resistance. There is a lack of oral solid preparations that can effectively suppress obesity, can be stored for a long time, are convenient to use, and are safe and have no side effects. It is of great significance to improve the quality of life of obese people

Method used

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  • Composition for suppressing obesity
  • Composition for suppressing obesity
  • Composition for suppressing obesity

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Experimental program
Comparison scheme
Effect test

preparation example Construction

[0034] In some of the embodiments of the present invention, preferably, the preparation method of the tablet of the composition comprises the following steps: poloxamer, spirulina, xylitol, citric acid, cross-linked polyvinylpyrrolidone, micronized silica gel and magnesium stearate are weighed according to the mass ratio of 84:7:1:2:8:0.5:0.5, mixed, and compressed into tablets to obtain tablets;

[0035] The preparation method of the granules of the composition comprises the following steps: poloxamer, spirulina, xylitol, citric acid, cross-linked polyvinylpyrrolidone, polyvinyl alcohol 6000 according to the mass ratio of 84:7:1:2 : 4:15 to weigh, mix, spray into absolute ethanol to moisten, extrude to make wet granules, and obtain granules after drying;

[0036] The preparation method of the capsule of the composition comprises the following steps: weighing poloxamer, spirulina, xylitol, citric acid, and cross-linked polyvinylpyrrolidone according to the mass ratio of 84:7:1...

Embodiment 1

[0042] Embodiment 1 preparation of oral solid preparation of composition for suppressing obesity

[0043] Experimental group: according to the composition of the experimental group in Table 1, each component was measured, and oral solid preparations were prepared according to the following steps.

[0044] (1) Preparation of tablets of the obesity-suppressing composition: poloxamer, spirulina, xylitol, citric acid, cross-linked polyvinylpyrrolidone, micronized silica gel and magnesium stearate in a mass ratio of 84:7: 1:2:8:0.5:0.5 were weighed, mixed, and tableted to obtain tablets of the obesity-suppressing composition.

[0045] (2) Preparation of granules of obesity-suppressing composition: poloxamer, spirulina, xylitol, citric acid, cross-linked polyvinylpyrrolidone, and polyvinyl alcohol 6000 in a mass ratio of 84:7:1:2 :4:15 to weigh, mix, spray into absolute ethanol for wetting, extrude with a 15-mesh sieve to make wet granules, evaporate the ethanol, shape and mix with...

Embodiment 2

[0054] Example 2 Evaluation of the application effect of the composition preparation for suppressing obesity

[0055] (1) Obesity model animals

[0056] According to the literature, the obesity model of miniature pigs was established. The method is briefly described as follows: Bama miniature pigs were fed with high-fat and high-sugar feed for 30 weeks, and compared with Bama miniature pigs fed with normal diet, the body shape index and CT scan fat content were measured. 1. Collect blood to detect biochemical indicators to determine the success of the obesity model.

[0057] (2) Stability investigation and application effect evaluation

[0058] Stability investigation: The oral solid preparations of the experimental group and the control group were subjected to accelerated experiments, placed under the conditions of temperature (40±2)°C and relative humidity (75±5)% for 6 months, observing their physical and chemical properties, and evaluating their stability The results are...

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Abstract

The invention discloses a composition with an effect of inhibiting obesity. The composition is prepared from poloxamer and spirulina. The composition with the effect of inhibiting obesity and an oralsolid preparation of the composition are organic wholes, the components are synergized to generate a complementary effect and achieve a safe and efficient obesity inhibiting effect.

Description

technical field [0001] The present invention relates to a composition, more particularly, to a composition for suppressing obesity. Background technique [0002] Obesity is a chronic metabolic disease in which body fat accumulates excessively and threatens health. Obesity is mainly related to factors such as diet, work and rest, physical fitness, heredity, age, gender, nature of work, mentality, and geography. With the improvement of residents' living standards, unreasonable diet structure, low intake of grains, high intake of high-fat and high-calorie food, lack of physical exercise and other factors lead to the increase of overweight and obesity. In my country's cities, there are about 15%-20% The incidence rate of the disease has a tendency to increase and become younger year by year. [0003] With the rapid increase in the incidence of obesity, obesity-related diseases are also on the rise. Obesity, in addition to leading to high blood pressure and diabetes, is also an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/748A61K47/10A61K36/76A61P3/04
CPCA61K9/0056A61K35/748A61K36/232A61K36/48A61K36/76A61K47/10A61P3/04A61K2300/00
Inventor 赵应征鲁翠涛徐荷林姚情吴伟
Owner WENZHOU MEDICAL UNIV
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