Combined detection of peripheral blood methylation gene and idh1 in the diagnosis of lung cancer model
A technology of IDH1, diagnostic model, applied in the medical field
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[0049] Example 1. Establishment and application of a lung cancer model diagnosed by combined detection of methylated genes and IDH1
[0050] 1. Research population
[0051] The methylation levels of SHOX2 and PTGER4 genes in the DNA of peripheral blood samples were measured and statistically analyzed in the samples of healthy controls and lung cancer patients, and the content of IDH1 protein in serum was detected. From January 2017 to December 2018, 221 subjects from the Cancer Hospital of the Chinese Academy of Medical Sciences were included in the study of the present invention and randomly divided into a modeling group and a verification group.
[0052] Blood samples were collected from lung cancer patients meeting the following criteria: (a) no history of other specific malignancies: (b) no anticancer treatment prior to the blood collection procedure.
[0053] The healthy people in the control group were selected from the physical examination center at the same time; as c...
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