The invention relates to the technical field of biological medicines, and discloses an application of a combined
gene in preparation of a product for diagnosing esophageal
squamous carcinoma. The combined
gene comprises the following genes of a CCL20
gene, a GSTP1 gene, an HSPB1 gene, a KRT14 gene, a KRT15 gene, an S100A8 gene, an S100A9 gene and a TACSTD2 gene. The invention also discloses an application of the combined gene in preparation of a pharmaceutical composition for treating the esophageal
squamous carcinoma. Compared with
single gene expression detection of the esophageal
squamous carcinoma in the prior art, the combined gene has higher specificity and higher diagnosis efficiency, can significantly improve the detection sensitivity and specificity, can accurately, conveniently and efficiently perform esophageal squamous
carcinoma early diagnosis and large-scale screening, and fills up the blank of an existing diagnosis technology, so that
effective treatment measures are provided for esophageal squamous
carcinoma patients in time, and prognosis is improved.