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A kind of quality control method of cough loquat syrup

A technology for cough-relieving loquat syrup and a detection method, which is applied in the directions of measuring devices, instruments, scientific instruments, etc., can solve the problems of single quality control, difficulty in comprehensively reflecting the taste of medicine, and few indicators, and achieves good reproducibility and ensures the controllable production process. , the effect of high accuracy

Active Publication Date: 2022-05-03
江西杏林白马药业股份有限公司
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Problems solved by technology

[0005] The present invention overcomes the defects of the prior art that basically only detects one or two components of a single Chinese herbal medicine in the content control of cough loquat syrup, single quality control, few indicators, and it is difficult to fully reflect the quality status of many medicinal flavors and many components. Based on this, combined with actual production efficiency, a quality control method for cough loquat syrup is provided

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  • A kind of quality control method of cough loquat syrup
  • A kind of quality control method of cough loquat syrup
  • A kind of quality control method of cough loquat syrup

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Embodiment 1

[0022] 1 Instruments and reagents

[0023] 1.1 Instrument

[0024] Agilent1290 liquid chromatograph (with photodiode array DAD detector), quaternary pump, autosampler, column thermostat, workstation); analytical balance (Germany Sartoriu company); Milli-Q ultrapure water (USA Millipore company) ; Vortex shaker (Germany IKA company), centrifuge (USA Beckman company).

[0025] 1.2 Reagent

[0026] Acetonitrile (chromatographically pure, German Merck Company), potassium dihydrogen phosphate (analytical pure, Sinopharm Chemical Reagent Co., Ltd.), glacial acetic acid (excellent grade, Sinopharm Chemical Reagent Co., Ltd.). Amygdalin (purity ≥ 99.0%, Chinese Academy of Sciences), Morusin B, and crotonine reference substance (purity ≥ 99.0%, Dr. Ehrensorfer, Germany). Cough-relieving loquat syrup is a commercially available product of Jiangxi Xinglin Baima Pharmaceutical Manufacturing Enterprise, 5 batches, 2 bottles per batch, 200mL / bottle.

[0027] 2 Methods and results

[00...

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Abstract

The invention discloses a quality control method for antitussive loquat syrup. In the method, an HPLC method is established for content determination of amygdalin, albanin B and phyllotine. The invention overcomes the defects in the prior art that only one or two components of a single Chinese herbal medicine are detected in the content control of the cough loquat syrup, the quality control is single, and the indicators are few, and it is difficult to fully reflect the quality status of the medicinal flavor and components. , combined with actual production efficiency. The quality control method of the present invention is reasonable in design, accurate and reliable, strong in specificity and simple in operation, can effectively control the drug quality in the production, circulation and use of the product, ensure the controllable production process, and ensure the safety of clinical use. The stable curative effect provides a reliable guarantee.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a quality control method for antitussive loquat syrup. Background technique [0002] Cough-relieving loquat syrup is a commonly used medicine for relieving cough and reducing phlegm. It has the effects of clearing the lung, relieving cough and reducing phlegm. It is used for the treatment of cough with phlegm and bronchitis. , Platycodon grandiflorum 78g, Baibu 94g, peppermint oil 3mL. At present, there are many domestic manufacturers of cough loquat syrup, with a total of 34 manufacturers and 34 approval numbers. [0003] The current quality standard for cough-relieving loquat syrup is "Ministry of Health Drug Standards", Volume Nine of Traditional Chinese Medicine Prescriptions) (WS3-B-1702-94). In view of the fact that the current standard is relatively old and lacks the determination of the content of the main components, some patents and documents h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/065
Inventor 胡志文
Owner 江西杏林白马药业股份有限公司
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