The invention relates to a medicine preparation for treating acne. The medicine preparation is prepared from, by weight, 7-15 parts of loquat leaves, 7-15 parts of white mulberry root-bark, 3-9 parts of coptis chinensis, 10-20 parts of golden cypress, 7-15 parts of gardenia jasminoides ellis, 7-15 parts of wild chrysanthemum flowers, 10-20 parts of honeysuckle, 10-20 parts of fructus forsythia, 7-15 parts of plantain herbs, 10-20 parts of roots of common peony, 20-30 parts of lalang grass rhizome, 10-20 parts of seaweed, 10-20 parts of sea-tangle, 10-20 parts of sea-tangle, 15-25 parts of raw oyster shells, 7-15 parts of raw rhizoma atractylodis macrocephalae, 10-20 parts of leonurus, 10-20 parts of thunberg fritillary bulbs, 7-15 parts of campsis grandiflora, 7-15 parts of pinellia ternate, 7-15 parts of stiff silkworms, 7-15 parts of wax gourd seeds, 7-15 parts of peach seeds and 7-15 parts of radix angelicae. The medicine preparation has a definite and stable curative effect on depression heat toxic factor intrinsic skin type common acne caused by 'heat', 'stasis' and 'depression', both symptoms and roots of disease are cured, the relapse rate is low after healing, and the medicine preparation is convenient to take, free of toxic or side effect and convenient to apply and popularize.