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A kind of ferric oxide bismuth sulfide nanocomposite material and its preparation and application

A nano-composite material, ferric oxide technology, applied in wave energy or particle radiation treatment materials, drug combinations, X-ray contrast agent preparation, etc., can solve the lack of image information, poor cell compatibility, utilization efficiency of photothermal materials low problems, to achieve the effects of excellent photothermal conversion efficiency, easy preparation, and good biocompatibility

Active Publication Date: 2022-08-02
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is: the existing photothermal materials lack image information inside the tumor, have poor cell compatibility and low utilization efficiency

Method used

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  • A kind of ferric oxide bismuth sulfide nanocomposite material and its preparation and application
  • A kind of ferric oxide bismuth sulfide nanocomposite material and its preparation and application
  • A kind of ferric oxide bismuth sulfide nanocomposite material and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] 0.32g of anhydrous FeCl 3 and 0.3 g PSSMA were dissolved in 20 mL of diethylene glycol, stirred at 60 °C for 30 min, and then 0.5 g CH 3 COONa was added to the mixture. After dissolving for 30 min, it was transferred to a 100 mL stainless steel reaction kettle lined with para-polyphenylene and sealed. The reaction kettle was placed in a high-temperature oven at 200°C for heat treatment for 7 hours, and after being naturally cooled to room temperature, the reaction mixture was centrifuged (8500 rpm, 5 min), and washed three times with distilled water and ethanol to obtain the product Fe 3 O 4 particles. The samples were finally vacuum dried for further use.

[0056] Dissolve 0.2 g of dopamine in 40 mL of Tris-HCl buffer solution (pH=8.5), then add 80 mg of Fe 3 O 4 particles. It was completely dispersed under the condition of ultrasound, placed on a shaker to react for 4 hours, the reaction mixture was centrifuged (8500 rpm, 5 min), and the product was washed thre...

Embodiment 2

[0060] Take a little Fe prepared in Example 1 3 O 4 @PDA@BSA-Bi 2 S 3 Particles, dispersed in distilled water, PBS, 1640 medium, Figure 1a -c shows that the hydration kinetic diameter of the material does not change significantly after being placed for 5 days, and the Tyndall phenomenon is obvious in the three systems, all of which have good colloidal stability. The morphology and microstructure of the material were observed by TEM. After ultrasonically dispersing an appropriate amount of nanosheets uniformly in absolute ethanol, the copper mesh coated with carbon film was immersed in the above-mentioned absolute ethanol. After the samples were naturally dried, they were observed and photographed by TEM (the operating voltage of the TEM was 200 kV). Depend on Figure 2a , 2b It can be seen that the material obtained in Example 1 has an ultra-small nanoparticle structure.

Embodiment 3

[0062] Fe prepared in Example 1 was measured and calculated using TGA (TGA-50 thermogravimetric analyzer) 3 O 4 @PDA@BSA-Bi 2 S 3 The percentage content of each component in the particles, respectively taking a certain mass of Fe 3 O 4 , Fe 3 O 4 @PDA, BSA-Bi 2 S, Fe 3 O 4 @PDA@BSA-Bi 2 S 3 The particles were added to the platinum crucible of the thermogravimetric analyzer. After reading the mass of the added sample, the experimental parameters were set to perform the TGA test. The test condition was to increase from room temperature to 800°C at 15°C / min in an air atmosphere. Fe prepared in Example 1 was tested and analyzed using FTIR (NicoletNexus 670 infrared spectrometer) 3 O 4 @PDA@BSA-Bi 2 S 3 The composition and structure of , take a little Fe 3 O 4 @PDA, BSA-Bi 2 S 3 , Fe 3 O 4 @PDA@BSA-Bi 2 S 3 The particles were mixed with a certain amount of potassium bromide (KBr) powder, and ground under an infrared lamp to ensure the dryness of the sample. Af...

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Abstract

The invention discloses a ferric oxide / bismuth sulfide nanocomposite material and its preparation. The preparation method is: the Fe 3 O 4 and dopamine are dispersed in Tris-HCl buffer solution to obtain Fe 3 O 4 @PDA nanoparticles; the bismuth source was dispersed in the solvent and then added dropwise to the bovine serum albumin solution to obtain BSA‑Bi 2 S 3 particles; Fe 3 O 4 @PDA nanoparticles dispersed into Na 2 HPO 4 ‑NaH 2 PO 4 buffer solution, add BSA‑Bi 2 S 3 particles, to obtain Fe 3 O 4 @PDA@BSA‑Bi 2 S 3 nanoparticles. The product obtained by the invention is easy to prepare and non-toxic, and has good biocompatibility, colloid stability and MRI&CT contrast effect at the level of cells and animals.

Description

technical field [0001] The invention relates to a contrastable bismuth ferric oxide bismuth sulfide nanocomposite material and its preparation and application, and belongs to the technical field of biological nanomaterials. Background technique [0002] Cancer (malignant tumor) is a large class of diseases characterized by abnormal cell proliferation and metastasis, and has become a major threat to human health and survival. Current clinical treatments for cancer include surgical resection, chemotherapy, and physical radiation therapy. Its main features are that surgery cannot completely remove all cancer cells in the human body under normal circumstances, and it is easy to relapse; chemotherapy uses drugs to kill cancer cells, but it is easy to develop drug resistance in the process of treatment; and physical radiation therapy will cause patients. Great harm and side effects. Therefore, early screening and diagnosis of cancer can help to formulate a reasonable treatment p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K33/26A61K47/69A61K49/04A61K49/12A61K49/18A61P35/00
CPCA61K41/0052A61K33/26A61K47/6935A61K47/6929A61K49/04A61K49/126A61K49/1869A61K49/183A61P35/00A61K49/0002A61K2300/00
Inventor 王世革罗科义
Owner UNIV OF SHANGHAI FOR SCI & TECH
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