Collagen-polyvinyl alcohol embolism microspheres loaded with iodine 131 and preparation method thereof

A technology for polyvinyl alcohol embolization microspheres and polyvinyl alcohol microspheres, which is applied in the field of clinical medical embolization treatment, can solve the problems of short half-life of glass microspheres, low specific activity of radioactivity, etc. The effect of uniform particle size distribution and smooth surface

Active Publication Date: 2020-06-05
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 90 The half-life of Y glass microspheres is short (64.1 hours), and the radioactive specific activity is not high. It must be activated in a special linear accelerator to obtain radioactive activity. Its short half-life and expensive activation equipment limit it to be used only in relatively low used by large medical centers

Method used

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  • Collagen-polyvinyl alcohol embolism microspheres loaded with iodine 131 and preparation method thereof
  • Collagen-polyvinyl alcohol embolism microspheres loaded with iodine 131 and preparation method thereof
  • Collagen-polyvinyl alcohol embolism microspheres loaded with iodine 131 and preparation method thereof

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Embodiment 1

[0046] Such as Figure 1-Figure 6 As shown, a preparation method of collagen-polyvinyl alcohol embolization microspheres loaded with iodine 131 comprises the following steps:

[0047] 1), using polyvinyl alcohol as raw material, adopting emulsification cross-linking method to prepare polyvinyl alcohol microspheres:

[0048] 11), prepare the polyvinyl alcohol microspheres into a polyvinyl alcohol solution with a concentration of 50 mg / mL, which is solution A;

[0049] 12), add Span80 or Tween80 to liquid paraffin, 500r / min fully stirs 10min to obtain solution B, the volume ratio of described liquid paraffin and emulsifier is 25:1;

[0050]13) Heat both solution A and solution B in a water bath to 50 degrees, under stirring (500r / min), add solution A to solution B dropwise with a sample gun, the volume of solution A and solution B The ratio is 1:10, continue to react for 30 minutes in a 50-degree water bath and 500r / min magnetic stirring, and obtain a milky white solution C; ...

Embodiment 2

[0063] This embodiment is based on embodiment 1, and the difference with embodiment 1 is:

[0064] The concentration of solution A is 10mg / mL; The volume ratio of described liquid paraffin and emulsifier is 10:1; The concentration of described collagen solution is 3.0mg / mL; The concentration of described collagen solution and polyvinyl alcohol microsphere suspension The volume ratio is 1:1.

Embodiment 3

[0066] This embodiment is based on embodiment 1, and the difference with embodiment 1 is:

[0067] The concentration of solution A is 100mg / mL; The volume ratio of described liquid paraffin and emulsifier is 40:1; The concentration of described collagen solution is 5.0mg / mL; The concentration of described collagen solution and polyvinyl alcohol microsphere suspension The volume ratio is 5:1.

[0068] Since the properties and effects of the iodine-131-loaded collagen-polyvinyl alcohol embolic microspheres prepared in Example 1, Example 2 and Example 3 are similar, they will not be elaborated one by one. Properties and effects of embolic microspheres.

[0069] The collagen-polyvinyl alcohol embolization microspheres (131I-PVA-COL1 microspheres) loaded with iodine 131 prepared in Example 1 were tested for labeling rate, and the detection method was:

[0070] Measure the labeling rate with paper chromatography, the stationary phase is Xinhua No. I paper, and the developing agent...

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Abstract

The invention discloses collagen-polyvinyl alcohol embolism microspheres loaded with iodine 131 and a preparation method thereof. The preparation method comprises the following steps: firstly, carrying out a crosslinking reaction on polyvinyl alcohol and type I collagen to prepare collagen-polyvinyl alcohol embolism microspheres, and then carrying out radioactive iodine 131 labeling on the collagen-polyvinyl alcohol embolism microspheres to obtain iodine 131-collagen-polyvinyl alcohol embolism microspheres. The embolism microspheres prepared by the invention not only can slow down the growth speed of tumors and prolong the longest lifetime of patients, but also have the advantages of small specific gravity, easiness in perfusion, long half-life period and capability of releasing gamma raysfor imaging monitoring, do not need expensive activation equipment, and are beneficial to reducing the cost.

Description

technical field [0001] The invention relates to the technical field of embolization therapy in clinical medicine, in particular to collagen-polyvinyl alcohol embolization microspheres loaded with iodine 131 and a preparation method thereof. Background technique [0002] Clinical hepatobiliary and pancreatic malignant tumors have low sensitivity to most chemotherapy drugs, and because of the deep tumor location, the liver and digestive tract are sensitive to radiation, resulting in poor efficacy of conventional external radiation therapy. In recent years, some large hospitals in China have begun to introduce 90 Y glass microspheres and 90 Y resin microspheres Embolization therapy for liver cancer. 90 Y microspheres are used for radioembolization of digestive tract solid tumors by releasing pure β-rays, and have been certified by the US Food and Drug Administration (FDA) for clinical liver cancer treatment. 90 Y glass microspheres are a foreign patented product, which i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02B01J13/14A61L31/02A61L31/04A61L31/14A61L31/18
CPCA61L31/028A61L31/044A61L31/048A61L31/14A61L31/18B01J13/02B01J13/14C08L29/04
Inventor 李玉豪蔡华伟李林庞富文
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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